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Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative

AIMS: Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if tel...

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Autores principales: Jiang, Xin, Dong, Ming, Cheng, Jinquan, Huang, Sichun, He, Yitao, Ma, Kefu, Tang, Bingshan, Guo, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702505/
https://www.ncbi.nlm.nih.gov/pubmed/23861874
http://dx.doi.org/10.1371/journal.pone.0068254
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author Jiang, Xin
Dong, Ming
Cheng, Jinquan
Huang, Sichun
He, Yitao
Ma, Kefu
Tang, Bingshan
Guo, Yi
author_facet Jiang, Xin
Dong, Ming
Cheng, Jinquan
Huang, Sichun
He, Yitao
Ma, Kefu
Tang, Bingshan
Guo, Yi
author_sort Jiang, Xin
collection PubMed
description AIMS: Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if telomere shortening was associated with stroke and whether this association was mainly due to inheritance or acquired cardiovascular risk factors. METHODS: Our study was focused on stroke in patients and their siblings. 450 subjects were recruited into this study: 150 patients with ischemic stroke as case group, 150 siblings of patients free of stroke (sibling group) and 150 healthy people as normal control. LTL was measured by real-time Polymerase Chain Reactions. The association between LTL and the cardiovascular risk factors was also determined. RESULTS: A significant decrease of LTL was found in case group when comparing with sibling (0.92±0.77 vs 1.68±1.24, p<0.001) and normal groups (0.92±0.77 vs 1.95±1.07, p<0.001), but no significant difference was found between sibling group and healthy control (p = 0.330). Shorter telomere length was independently associated with hypertension (p = 0.029, OR = 2.189, 95%CI:1.084–4.421), recent social pressure (p = 0.001, OR = 3.121, 95%CI:1.597–6.101), age (p = 0.004, OR = 1.055, 95%CI:1.017–1.093), HDL (p = 0.022, OR = 0.227, 95%CI:0.064–0.810) and diabetes (p = 0.018, OR = 3.174, 95%CI:1.221–8.252). Additionally, shortened length of telomere (p = 0.017, OR = 3.996, 95%CI:1.283–12.774) was an independent risk biomarker for stroke among case and sibling groups. CONCLUSION: The present study has demonstrated that decreased LTL might be associated with ischemic stroke but unlikely to be causative.
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spelling pubmed-37025052013-07-16 Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative Jiang, Xin Dong, Ming Cheng, Jinquan Huang, Sichun He, Yitao Ma, Kefu Tang, Bingshan Guo, Yi PLoS One Research Article AIMS: Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if telomere shortening was associated with stroke and whether this association was mainly due to inheritance or acquired cardiovascular risk factors. METHODS: Our study was focused on stroke in patients and their siblings. 450 subjects were recruited into this study: 150 patients with ischemic stroke as case group, 150 siblings of patients free of stroke (sibling group) and 150 healthy people as normal control. LTL was measured by real-time Polymerase Chain Reactions. The association between LTL and the cardiovascular risk factors was also determined. RESULTS: A significant decrease of LTL was found in case group when comparing with sibling (0.92±0.77 vs 1.68±1.24, p<0.001) and normal groups (0.92±0.77 vs 1.95±1.07, p<0.001), but no significant difference was found between sibling group and healthy control (p = 0.330). Shorter telomere length was independently associated with hypertension (p = 0.029, OR = 2.189, 95%CI:1.084–4.421), recent social pressure (p = 0.001, OR = 3.121, 95%CI:1.597–6.101), age (p = 0.004, OR = 1.055, 95%CI:1.017–1.093), HDL (p = 0.022, OR = 0.227, 95%CI:0.064–0.810) and diabetes (p = 0.018, OR = 3.174, 95%CI:1.221–8.252). Additionally, shortened length of telomere (p = 0.017, OR = 3.996, 95%CI:1.283–12.774) was an independent risk biomarker for stroke among case and sibling groups. CONCLUSION: The present study has demonstrated that decreased LTL might be associated with ischemic stroke but unlikely to be causative. Public Library of Science 2013-07-05 /pmc/articles/PMC3702505/ /pubmed/23861874 http://dx.doi.org/10.1371/journal.pone.0068254 Text en © 2013 Jiang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jiang, Xin
Dong, Ming
Cheng, Jinquan
Huang, Sichun
He, Yitao
Ma, Kefu
Tang, Bingshan
Guo, Yi
Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
title Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
title_full Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
title_fullStr Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
title_full_unstemmed Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
title_short Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
title_sort decreased leukocyte telomere length (ltl) is associated with stroke but unlikely to be causative
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702505/
https://www.ncbi.nlm.nih.gov/pubmed/23861874
http://dx.doi.org/10.1371/journal.pone.0068254
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