Cargando…
Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative
AIMS: Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if tel...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702505/ https://www.ncbi.nlm.nih.gov/pubmed/23861874 http://dx.doi.org/10.1371/journal.pone.0068254 |
_version_ | 1782275822097268736 |
---|---|
author | Jiang, Xin Dong, Ming Cheng, Jinquan Huang, Sichun He, Yitao Ma, Kefu Tang, Bingshan Guo, Yi |
author_facet | Jiang, Xin Dong, Ming Cheng, Jinquan Huang, Sichun He, Yitao Ma, Kefu Tang, Bingshan Guo, Yi |
author_sort | Jiang, Xin |
collection | PubMed |
description | AIMS: Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if telomere shortening was associated with stroke and whether this association was mainly due to inheritance or acquired cardiovascular risk factors. METHODS: Our study was focused on stroke in patients and their siblings. 450 subjects were recruited into this study: 150 patients with ischemic stroke as case group, 150 siblings of patients free of stroke (sibling group) and 150 healthy people as normal control. LTL was measured by real-time Polymerase Chain Reactions. The association between LTL and the cardiovascular risk factors was also determined. RESULTS: A significant decrease of LTL was found in case group when comparing with sibling (0.92±0.77 vs 1.68±1.24, p<0.001) and normal groups (0.92±0.77 vs 1.95±1.07, p<0.001), but no significant difference was found between sibling group and healthy control (p = 0.330). Shorter telomere length was independently associated with hypertension (p = 0.029, OR = 2.189, 95%CI:1.084–4.421), recent social pressure (p = 0.001, OR = 3.121, 95%CI:1.597–6.101), age (p = 0.004, OR = 1.055, 95%CI:1.017–1.093), HDL (p = 0.022, OR = 0.227, 95%CI:0.064–0.810) and diabetes (p = 0.018, OR = 3.174, 95%CI:1.221–8.252). Additionally, shortened length of telomere (p = 0.017, OR = 3.996, 95%CI:1.283–12.774) was an independent risk biomarker for stroke among case and sibling groups. CONCLUSION: The present study has demonstrated that decreased LTL might be associated with ischemic stroke but unlikely to be causative. |
format | Online Article Text |
id | pubmed-3702505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37025052013-07-16 Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative Jiang, Xin Dong, Ming Cheng, Jinquan Huang, Sichun He, Yitao Ma, Kefu Tang, Bingshan Guo, Yi PLoS One Research Article AIMS: Interindividual variability in telomere length is highly heritable. Leukocyte telomere length (LTL) shortening has been shown to be associated with the process of atherosclerosis. But whether the inheritance of LTL is related to stroke is still unclear. The aim of this study was to test if telomere shortening was associated with stroke and whether this association was mainly due to inheritance or acquired cardiovascular risk factors. METHODS: Our study was focused on stroke in patients and their siblings. 450 subjects were recruited into this study: 150 patients with ischemic stroke as case group, 150 siblings of patients free of stroke (sibling group) and 150 healthy people as normal control. LTL was measured by real-time Polymerase Chain Reactions. The association between LTL and the cardiovascular risk factors was also determined. RESULTS: A significant decrease of LTL was found in case group when comparing with sibling (0.92±0.77 vs 1.68±1.24, p<0.001) and normal groups (0.92±0.77 vs 1.95±1.07, p<0.001), but no significant difference was found between sibling group and healthy control (p = 0.330). Shorter telomere length was independently associated with hypertension (p = 0.029, OR = 2.189, 95%CI:1.084–4.421), recent social pressure (p = 0.001, OR = 3.121, 95%CI:1.597–6.101), age (p = 0.004, OR = 1.055, 95%CI:1.017–1.093), HDL (p = 0.022, OR = 0.227, 95%CI:0.064–0.810) and diabetes (p = 0.018, OR = 3.174, 95%CI:1.221–8.252). Additionally, shortened length of telomere (p = 0.017, OR = 3.996, 95%CI:1.283–12.774) was an independent risk biomarker for stroke among case and sibling groups. CONCLUSION: The present study has demonstrated that decreased LTL might be associated with ischemic stroke but unlikely to be causative. Public Library of Science 2013-07-05 /pmc/articles/PMC3702505/ /pubmed/23861874 http://dx.doi.org/10.1371/journal.pone.0068254 Text en © 2013 Jiang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Jiang, Xin Dong, Ming Cheng, Jinquan Huang, Sichun He, Yitao Ma, Kefu Tang, Bingshan Guo, Yi Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative |
title | Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative |
title_full | Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative |
title_fullStr | Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative |
title_full_unstemmed | Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative |
title_short | Decreased Leukocyte Telomere Length (LTL) Is Associated with Stroke but Unlikely to Be Causative |
title_sort | decreased leukocyte telomere length (ltl) is associated with stroke but unlikely to be causative |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702505/ https://www.ncbi.nlm.nih.gov/pubmed/23861874 http://dx.doi.org/10.1371/journal.pone.0068254 |
work_keys_str_mv | AT jiangxin decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT dongming decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT chengjinquan decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT huangsichun decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT heyitao decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT makefu decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT tangbingshan decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative AT guoyi decreasedleukocytetelomerelengthltlisassociatedwithstrokebutunlikelytobecausative |