Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK activity has been postulated to be an important int...

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Detalles Bibliográficos
Autores principales: Rex, Karen, Jeffries, Shawn, Brown, Matthew L., Carlson, Timothy, Coxon, Angela, Fajardo, Flordeliza, Frank, Brendon, Gustin, Darin, Kamb, Alexander, Kassner, Paul D., Li, Shyun, Li, Yihong, Morgenstern, Kurt, Plant, Matthew, Quon, Kim, Ruefli-Brasse, Astrid, Schmidt, Joanna, Swearingen, Elissa, Walker, Nigel, Wang, Zhulun, Watson, J. E. Vivienne, Wickramasinghe, Dineli, Wong, Mariwil, Xu, Guifen, Wesche, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702540/
https://www.ncbi.nlm.nih.gov/pubmed/23861887
http://dx.doi.org/10.1371/journal.pone.0068328

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