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Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase

The ‘radical S-adenosyl-L-methionine (AdoMet)’ enzyme Cfr methylates adenosine 2503 of the 23S rRNA in the peptidyltransferase centre (P-site) of the bacterial ribosome. This modification protects host bacteria, notably methicillin-resistant Staphylococcus aureus (MRSA), from numerous antibiotics, i...

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Detalles Bibliográficos
Autores principales:	Challand, Martin R., Salvadori, Enrico, Driesener, Rebecca C., Kay, Christopher W. M., Roach, Peter L., Spencer, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702613/ https://www.ncbi.nlm.nih.gov/pubmed/23861844 http://dx.doi.org/10.1371/journal.pone.0067979

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