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The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats
Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed to investigate the effects of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. Eug...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702691/ https://www.ncbi.nlm.nih.gov/pubmed/23837051 http://dx.doi.org/10.3892/etm.2013.1066 |
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author | XU, JING-SHU LI, YAO CAO, XUE CUI, YUN |
author_facet | XU, JING-SHU LI, YAO CAO, XUE CUI, YUN |
author_sort | XU, JING-SHU |
collection | PubMed |
description | Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed to investigate the effects of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. Eugenol demonstrated significant inhibitory effects against acid production by S. mutans. The synthesis of water-insoluble glucans by glucosyltransferases was reduced by eugenol. Eugenol also markedly suppressed the adherence of S. mutans to saliva-coated hydroxyapatite beads. Furthermore, topical application of eugenol reduced the incidence and severity of carious lesions in rats. These results suggest that the natural compound eugenol may be a useful therapeutic agent for dental caries. |
format | Online Article Text |
id | pubmed-3702691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37026912013-07-08 The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats XU, JING-SHU LI, YAO CAO, XUE CUI, YUN Exp Ther Med Articles Eugenol has been widely used in medicine due to its antibacterial, anti-inflammatory, antioxidant, anticancer and analgesic properties. The present study was designed to investigate the effects of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. Eugenol demonstrated significant inhibitory effects against acid production by S. mutans. The synthesis of water-insoluble glucans by glucosyltransferases was reduced by eugenol. Eugenol also markedly suppressed the adherence of S. mutans to saliva-coated hydroxyapatite beads. Furthermore, topical application of eugenol reduced the incidence and severity of carious lesions in rats. These results suggest that the natural compound eugenol may be a useful therapeutic agent for dental caries. D.A. Spandidos 2013-06 2013-04-17 /pmc/articles/PMC3702691/ /pubmed/23837051 http://dx.doi.org/10.3892/etm.2013.1066 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles XU, JING-SHU LI, YAO CAO, XUE CUI, YUN The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats |
title | The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats |
title_full | The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats |
title_fullStr | The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats |
title_full_unstemmed | The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats |
title_short | The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats |
title_sort | effect of eugenol on the cariogenic properties of streptococcus mutans and dental caries development in rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702691/ https://www.ncbi.nlm.nih.gov/pubmed/23837051 http://dx.doi.org/10.3892/etm.2013.1066 |
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