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Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus

The aim of the present study was to investigate the sensitivity and specificity of anti-Sjögren’s syndrome type B (SSB) antibodies for diagnosing systemic lupus erythematosus (SLE) and to understand the correlation between anti-SSB antibodies and the clinical manifestations of SLE. A line immunoassa...

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Autores principales: RAO, LI, LIU, GUIYAN, LI, CHUNFEN, LI, YAJUAN, WANG, ZHIGUO, ZHOU, ZIJIAO, TONG, SHENGQUAN, WU, XIANMING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702711/
https://www.ncbi.nlm.nih.gov/pubmed/23837059
http://dx.doi.org/10.3892/etm.2013.1051
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author RAO, LI
LIU, GUIYAN
LI, CHUNFEN
LI, YAJUAN
WANG, ZHIGUO
ZHOU, ZIJIAO
TONG, SHENGQUAN
WU, XIANMING
author_facet RAO, LI
LIU, GUIYAN
LI, CHUNFEN
LI, YAJUAN
WANG, ZHIGUO
ZHOU, ZIJIAO
TONG, SHENGQUAN
WU, XIANMING
author_sort RAO, LI
collection PubMed
description The aim of the present study was to investigate the sensitivity and specificity of anti-Sjögren’s syndrome type B (SSB) antibodies for diagnosing systemic lupus erythematosus (SLE) and to understand the correlation between anti-SSB antibodies and the clinical manifestations of SLE. A line immunoassay (LIA) was used to detect the presence of serum anti-SSB antibodies in SLE patients. The clinical manifestations of the patients were recorded to enable their correlation with the serum anti-SSB antibodies to be analyzed. In 25.7% of the 74 SLE patients, the serum was positive for anti-SSB antibodies, whereas only 3.3% of the 30 control cases were positive. The specificity of anti-SSB antibodies for detecting SLE was 96.7%. In anti-SSB antibody-positive SLE patients, the incidence of cheek erythema, alopecia, serositis, secondary Sjögren’s syndrome (sSS), leukocytopenia, elevated immunoglobulin (Ig)G and positive presence of anti-Sjögren’s syndrome type A (SSA)60 or anti-SSA52 antibodies was higher than in the anti-SSB antibody-negative group (P<0.05). Anti-SSB antibodies are important for the diagnosis of SLE and are associated with cheek erythema, alopecia, serositis, sSS, leukocytopenia, the elevation of IgG and positive presence of anti-SSA60 or anti-SSA52 antibodies.
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spelling pubmed-37027112013-07-08 Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus RAO, LI LIU, GUIYAN LI, CHUNFEN LI, YAJUAN WANG, ZHIGUO ZHOU, ZIJIAO TONG, SHENGQUAN WU, XIANMING Exp Ther Med Articles The aim of the present study was to investigate the sensitivity and specificity of anti-Sjögren’s syndrome type B (SSB) antibodies for diagnosing systemic lupus erythematosus (SLE) and to understand the correlation between anti-SSB antibodies and the clinical manifestations of SLE. A line immunoassay (LIA) was used to detect the presence of serum anti-SSB antibodies in SLE patients. The clinical manifestations of the patients were recorded to enable their correlation with the serum anti-SSB antibodies to be analyzed. In 25.7% of the 74 SLE patients, the serum was positive for anti-SSB antibodies, whereas only 3.3% of the 30 control cases were positive. The specificity of anti-SSB antibodies for detecting SLE was 96.7%. In anti-SSB antibody-positive SLE patients, the incidence of cheek erythema, alopecia, serositis, secondary Sjögren’s syndrome (sSS), leukocytopenia, elevated immunoglobulin (Ig)G and positive presence of anti-Sjögren’s syndrome type A (SSA)60 or anti-SSA52 antibodies was higher than in the anti-SSB antibody-negative group (P<0.05). Anti-SSB antibodies are important for the diagnosis of SLE and are associated with cheek erythema, alopecia, serositis, sSS, leukocytopenia, the elevation of IgG and positive presence of anti-SSA60 or anti-SSA52 antibodies. D.A. Spandidos 2013-06 2013-04-08 /pmc/articles/PMC3702711/ /pubmed/23837059 http://dx.doi.org/10.3892/etm.2013.1051 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
RAO, LI
LIU, GUIYAN
LI, CHUNFEN
LI, YAJUAN
WANG, ZHIGUO
ZHOU, ZIJIAO
TONG, SHENGQUAN
WU, XIANMING
Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
title Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
title_full Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
title_fullStr Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
title_full_unstemmed Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
title_short Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus
title_sort specificity of anti-ssb as a diagnostic marker for the classification of systemic lupus erythematosus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702711/
https://www.ncbi.nlm.nih.gov/pubmed/23837059
http://dx.doi.org/10.3892/etm.2013.1051
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