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Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis

BACKGROUND: Glomerular filtration rate (GFR) is widely estimated by serum creatinine based equations such as Cockcroft-Gault (CG) standardized for body surface, and an abbreviated formula derived from MDRD (modification of diet in renal disease) study. However, some studies suggested that creatinine...

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Autores principales: Khorgami, Zhinoos, Abdollahi, Alireza, Soleimani, Samaneh, Ahamadi, Farrokhlagha, Mahdavi-Mazdeh, Mitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703130/
https://www.ncbi.nlm.nih.gov/pubmed/23841035
http://dx.doi.org/10.5812/numonthly.4934
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author Khorgami, Zhinoos
Abdollahi, Alireza
Soleimani, Samaneh
Ahamadi, Farrokhlagha
Mahdavi-Mazdeh, Mitra
author_facet Khorgami, Zhinoos
Abdollahi, Alireza
Soleimani, Samaneh
Ahamadi, Farrokhlagha
Mahdavi-Mazdeh, Mitra
author_sort Khorgami, Zhinoos
collection PubMed
description BACKGROUND: Glomerular filtration rate (GFR) is widely estimated by serum creatinine based equations such as Cockcroft-Gault (CG) standardized for body surface, and an abbreviated formula derived from MDRD (modification of diet in renal disease) study. However, some studies suggested that creatinine based estimation of GFR formula can be replaced by cystatin C based formula. OBJECTIVES: The aim of this study was to determine whether cystatin C based equation could be used as an indicator for renal function in hemodialysis patients compared to MDRD equation; and whether cystatin C, a dialyzable molecule, was related to Kt/V, the marker for dialysis adequacy. PATIENTS AND METHODS: In this cross-sectional study, 98 patients on chronic hemodialysis were included. Plasma levels of urea and creatinine were measured before and after dialysis, and cystatin C was measured before dialysis. GFR was calculated and compared. RESULTS: The mean age of patients was 55.50 ± 16.10 (24-86) years and 66 cases were male (67.3%). The GFR was estimated at 6.05 ± 2.36 and 5.83 ± 2.19 cc/min by MDRD and cystatin C based formulas, respectively, with a significant correlation (r = 0.51; P < 0.001). Serum cystatin C level was 9.74 ± 2.47 mg/L which showed significant reverse correlation with both MDRD (r = -0.46; P < 0.001) and cystatin C based formulas (r = -0.87; P < 0.001). Neither creatinine nor serum cystatin C showed correlation with Kt/V, as the marker of dialysis adequacy. CONCLUSIONS: Serum cystatin C may be considered as an indicator of renal function in patients under maintenance hemodialysis.
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spelling pubmed-37031302013-07-09 Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis Khorgami, Zhinoos Abdollahi, Alireza Soleimani, Samaneh Ahamadi, Farrokhlagha Mahdavi-Mazdeh, Mitra Nephrourol Mon Research Article BACKGROUND: Glomerular filtration rate (GFR) is widely estimated by serum creatinine based equations such as Cockcroft-Gault (CG) standardized for body surface, and an abbreviated formula derived from MDRD (modification of diet in renal disease) study. However, some studies suggested that creatinine based estimation of GFR formula can be replaced by cystatin C based formula. OBJECTIVES: The aim of this study was to determine whether cystatin C based equation could be used as an indicator for renal function in hemodialysis patients compared to MDRD equation; and whether cystatin C, a dialyzable molecule, was related to Kt/V, the marker for dialysis adequacy. PATIENTS AND METHODS: In this cross-sectional study, 98 patients on chronic hemodialysis were included. Plasma levels of urea and creatinine were measured before and after dialysis, and cystatin C was measured before dialysis. GFR was calculated and compared. RESULTS: The mean age of patients was 55.50 ± 16.10 (24-86) years and 66 cases were male (67.3%). The GFR was estimated at 6.05 ± 2.36 and 5.83 ± 2.19 cc/min by MDRD and cystatin C based formulas, respectively, with a significant correlation (r = 0.51; P < 0.001). Serum cystatin C level was 9.74 ± 2.47 mg/L which showed significant reverse correlation with both MDRD (r = -0.46; P < 0.001) and cystatin C based formulas (r = -0.87; P < 0.001). Neither creatinine nor serum cystatin C showed correlation with Kt/V, as the marker of dialysis adequacy. CONCLUSIONS: Serum cystatin C may be considered as an indicator of renal function in patients under maintenance hemodialysis. Kowsar 2013 2013-03-30 /pmc/articles/PMC3703130/ /pubmed/23841035 http://dx.doi.org/10.5812/numonthly.4934 Text en Copyright © 2013, Nephrology and Urology Research Center http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khorgami, Zhinoos
Abdollahi, Alireza
Soleimani, Samaneh
Ahamadi, Farrokhlagha
Mahdavi-Mazdeh, Mitra
Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis
title Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis
title_full Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis
title_fullStr Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis
title_full_unstemmed Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis
title_short Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis
title_sort relationship between serum cystatin c and creatinine or dialysis adequacy in patients on chronic maintenance hemodialysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703130/
https://www.ncbi.nlm.nih.gov/pubmed/23841035
http://dx.doi.org/10.5812/numonthly.4934
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