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Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles

BACKGROUND: Skeletal muscle is one of the most important economic traits in agricultural animals, especially in pigs. In the modern pig industry, lean type pigs have undergone strong artificial selection for muscle growth, which has led to remarkable phenotypic variations compared with fatty type pi...

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Autores principales: Zhang, Jie, Zhou, Chaowei, Ma, Jideng, Chen, Lei, Jiang, Anan, Zhu, Li, Shuai, Surong, Wang, Jinyong, Li, Mingzhou, Li, Xuewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703266/
https://www.ncbi.nlm.nih.gov/pubmed/23768211
http://dx.doi.org/10.1186/1471-2156-14-53
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author Zhang, Jie
Zhou, Chaowei
Ma, Jideng
Chen, Lei
Jiang, Anan
Zhu, Li
Shuai, Surong
Wang, Jinyong
Li, Mingzhou
Li, Xuewei
author_facet Zhang, Jie
Zhou, Chaowei
Ma, Jideng
Chen, Lei
Jiang, Anan
Zhu, Li
Shuai, Surong
Wang, Jinyong
Li, Mingzhou
Li, Xuewei
author_sort Zhang, Jie
collection PubMed
description BACKGROUND: Skeletal muscle is one of the most important economic traits in agricultural animals, especially in pigs. In the modern pig industry, lean type pigs have undergone strong artificial selection for muscle growth, which has led to remarkable phenotypic variations compared with fatty type pigs, making these different breeds an ideal model for comparative studies. RESULTS: Here, we present comprehensive gene expression profiling for the white (longissimus dorsi muscle) and the red (psoas major muscle) skeletal muscles among male and female fatty Rongchang, feral Tibetan and lean Landrace pigs, using a microarray approach. We identified differentially expressed genes that may be associated the phenotypic differences of porcine muscles among the breeds, between the sexes and the anatomical locations. We also used a clustering method to identify sets of functionally coexpressed genes that are linked to different muscle phenotypes. We showed that, compared with the white muscles, which primarily modulate metabolic processes, the red muscles show a tendency to be a risk factor for inflammation and immune-related disorders. CONCLUSIONS: This analysis presents breed-, sex- and anatomical location-specific gene expression profiles and further identified genes that may be associated with the phenotypic differences in porcine muscles among breeds, between the sexes and the anatomical locations.
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spelling pubmed-37032662013-07-07 Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles Zhang, Jie Zhou, Chaowei Ma, Jideng Chen, Lei Jiang, Anan Zhu, Li Shuai, Surong Wang, Jinyong Li, Mingzhou Li, Xuewei BMC Genet Research Article BACKGROUND: Skeletal muscle is one of the most important economic traits in agricultural animals, especially in pigs. In the modern pig industry, lean type pigs have undergone strong artificial selection for muscle growth, which has led to remarkable phenotypic variations compared with fatty type pigs, making these different breeds an ideal model for comparative studies. RESULTS: Here, we present comprehensive gene expression profiling for the white (longissimus dorsi muscle) and the red (psoas major muscle) skeletal muscles among male and female fatty Rongchang, feral Tibetan and lean Landrace pigs, using a microarray approach. We identified differentially expressed genes that may be associated the phenotypic differences of porcine muscles among the breeds, between the sexes and the anatomical locations. We also used a clustering method to identify sets of functionally coexpressed genes that are linked to different muscle phenotypes. We showed that, compared with the white muscles, which primarily modulate metabolic processes, the red muscles show a tendency to be a risk factor for inflammation and immune-related disorders. CONCLUSIONS: This analysis presents breed-, sex- and anatomical location-specific gene expression profiles and further identified genes that may be associated with the phenotypic differences in porcine muscles among breeds, between the sexes and the anatomical locations. BioMed Central 2013-06-15 /pmc/articles/PMC3703266/ /pubmed/23768211 http://dx.doi.org/10.1186/1471-2156-14-53 Text en Copyright © 2013 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Jie
Zhou, Chaowei
Ma, Jideng
Chen, Lei
Jiang, Anan
Zhu, Li
Shuai, Surong
Wang, Jinyong
Li, Mingzhou
Li, Xuewei
Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
title Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
title_full Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
title_fullStr Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
title_full_unstemmed Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
title_short Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
title_sort breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703266/
https://www.ncbi.nlm.nih.gov/pubmed/23768211
http://dx.doi.org/10.1186/1471-2156-14-53
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