Cargando…

Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy

BACKGROUND: Respiratory syncytial virus (RSV) infection in infancy is associated with subsequent recurrent wheezing. METHODS: A retrospective cohort study examined children born at ≥32 weeks gestation between 1996–2004. All children were enrolled in an integrated health care delivery system in North...

Descripción completa

Detalles Bibliográficos
Autores principales: Escobar, Gabriel J, Masaquel, Anthony S, Li, Sherian X, Walsh, Eileen M, Kipnis, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703269/
https://www.ncbi.nlm.nih.gov/pubmed/23782528
http://dx.doi.org/10.1186/1471-2431-13-97
_version_ 1782275879277166592
author Escobar, Gabriel J
Masaquel, Anthony S
Li, Sherian X
Walsh, Eileen M
Kipnis, Patricia
author_facet Escobar, Gabriel J
Masaquel, Anthony S
Li, Sherian X
Walsh, Eileen M
Kipnis, Patricia
author_sort Escobar, Gabriel J
collection PubMed
description BACKGROUND: Respiratory syncytial virus (RSV) infection in infancy is associated with subsequent recurrent wheezing. METHODS: A retrospective cohort study examined children born at ≥32 weeks gestation between 1996–2004. All children were enrolled in an integrated health care delivery system in Northern California and were followed through the fifth year of life. The primary endpoint was recurrent wheezing in the fifth year of life and its association with laboratory-confirmed, medically-attended RSV infection during the first year, prematurity, and supplemental oxygen during birth hospitalization. Other outcomes measured were recurrent wheezing quantified through outpatient visits, inpatient hospital stays, and asthma prescriptions. RESULTS: The study sample included 72,602 children. The rate of recurrent wheezing in the second year was 5.6% and fell to 4.7% by the fifth year. Recurrent wheezing rates varied by risk status: the rate was 12.5% among infants with RSV hospitalization, 8% among infants 32–33 weeks gestation, and 18% in infants with bronchopulmonary dysplasia. In multivariate analyses, increasing severity of respiratory syncytial virus infection was significantly associated with recurrent wheezing in year 5; compared with children without RSV infection in infancy, children who only had an outpatient RSV encounter had an adjusted odds ratio of 1.38 (95% CI,1.03–1.85), while children with a prolonged RSV hospitalization had an adjusted odds ratio of 2.59 (95% CI, 1.49–4.50). CONCLUSIONS: Laboratory-confirmed, medically attended RSV infection, prematurity, and neonatal exposure to supplemental oxygen have independent associations with development of recurrent wheezing in the fifth year of life.
format Online
Article
Text
id pubmed-3703269
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-37032692013-07-07 Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy Escobar, Gabriel J Masaquel, Anthony S Li, Sherian X Walsh, Eileen M Kipnis, Patricia BMC Pediatr Research Article BACKGROUND: Respiratory syncytial virus (RSV) infection in infancy is associated with subsequent recurrent wheezing. METHODS: A retrospective cohort study examined children born at ≥32 weeks gestation between 1996–2004. All children were enrolled in an integrated health care delivery system in Northern California and were followed through the fifth year of life. The primary endpoint was recurrent wheezing in the fifth year of life and its association with laboratory-confirmed, medically-attended RSV infection during the first year, prematurity, and supplemental oxygen during birth hospitalization. Other outcomes measured were recurrent wheezing quantified through outpatient visits, inpatient hospital stays, and asthma prescriptions. RESULTS: The study sample included 72,602 children. The rate of recurrent wheezing in the second year was 5.6% and fell to 4.7% by the fifth year. Recurrent wheezing rates varied by risk status: the rate was 12.5% among infants with RSV hospitalization, 8% among infants 32–33 weeks gestation, and 18% in infants with bronchopulmonary dysplasia. In multivariate analyses, increasing severity of respiratory syncytial virus infection was significantly associated with recurrent wheezing in year 5; compared with children without RSV infection in infancy, children who only had an outpatient RSV encounter had an adjusted odds ratio of 1.38 (95% CI,1.03–1.85), while children with a prolonged RSV hospitalization had an adjusted odds ratio of 2.59 (95% CI, 1.49–4.50). CONCLUSIONS: Laboratory-confirmed, medically attended RSV infection, prematurity, and neonatal exposure to supplemental oxygen have independent associations with development of recurrent wheezing in the fifth year of life. BioMed Central 2013-06-19 /pmc/articles/PMC3703269/ /pubmed/23782528 http://dx.doi.org/10.1186/1471-2431-13-97 Text en Copyright © 2013 Escobar et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Escobar, Gabriel J
Masaquel, Anthony S
Li, Sherian X
Walsh, Eileen M
Kipnis, Patricia
Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
title Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
title_full Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
title_fullStr Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
title_full_unstemmed Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
title_short Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
title_sort persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703269/
https://www.ncbi.nlm.nih.gov/pubmed/23782528
http://dx.doi.org/10.1186/1471-2431-13-97
work_keys_str_mv AT escobargabrielj persistentrecurringwheezinginthefifthyearoflifeafterlaboratoryconfirmedmedicallyattendedrespiratorysyncytialvirusinfectionininfancy
AT masaquelanthonys persistentrecurringwheezinginthefifthyearoflifeafterlaboratoryconfirmedmedicallyattendedrespiratorysyncytialvirusinfectionininfancy
AT lisherianx persistentrecurringwheezinginthefifthyearoflifeafterlaboratoryconfirmedmedicallyattendedrespiratorysyncytialvirusinfectionininfancy
AT walsheileenm persistentrecurringwheezinginthefifthyearoflifeafterlaboratoryconfirmedmedicallyattendedrespiratorysyncytialvirusinfectionininfancy
AT kipnispatricia persistentrecurringwheezinginthefifthyearoflifeafterlaboratoryconfirmedmedicallyattendedrespiratorysyncytialvirusinfectionininfancy