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Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus
The hormonally active form of vitamin D(3), 1,25(OH)(2)D(3) (calcitriol), exerts actions through VDR receptor, which acts as a transcriptional factor. Calcitriol is an immunomodulator that affects various immune cells, and several studies link it to many autoimmune diseases. BsmI polymorphism affect...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703334/ https://www.ncbi.nlm.nih.gov/pubmed/23853726 http://dx.doi.org/10.1155/2013/427818 |
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author | Kaleta, Beata Bogaczewicz, Jarosław Robak, Ewa Sysa-Jędrzejowska, Anna Wrzosek, Małgorzata Szubierajska, Weronika Mróz, Piotr Łukaszkiewicz, Jacek Woźniacka, Anna |
author_facet | Kaleta, Beata Bogaczewicz, Jarosław Robak, Ewa Sysa-Jędrzejowska, Anna Wrzosek, Małgorzata Szubierajska, Weronika Mróz, Piotr Łukaszkiewicz, Jacek Woźniacka, Anna |
author_sort | Kaleta, Beata |
collection | PubMed |
description | The hormonally active form of vitamin D(3), 1,25(OH)(2)D(3) (calcitriol), exerts actions through VDR receptor, which acts as a transcriptional factor. Calcitriol is an immunomodulator that affects various immune cells, and several studies link it to many autoimmune diseases. BsmI polymorphism affects the level of VDR gene transcription, transcript stability, and posttranscriptional modifications. It seems to be related to the systemic lupus erythematosus (SLE). Our study examined the characteristics of VDR gene BsmI polymorphism in Polish SLE patients and their relationship with clinical manifestations of the disease. We genotyped 62 patients with SLE and 100 healthy controls using the real-time PCR. There were no differences observed in the frequency of BsmI genotypes in SLE patients and in the control group. There was no significant correlation between BsmI genotypes and clinical symptoms of SLE, but the AA genotype correlates with higher levels of antinuclear antibodies (ANA) in this group (r = 0.438; P = 0.002). A larger study examining BsmI and other VDR gene polymorphisms is needed. It may allow explaining differences in the clinical picture of the disease and choosing a personalized therapy. |
format | Online Article Text |
id | pubmed-3703334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37033342013-07-12 Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus Kaleta, Beata Bogaczewicz, Jarosław Robak, Ewa Sysa-Jędrzejowska, Anna Wrzosek, Małgorzata Szubierajska, Weronika Mróz, Piotr Łukaszkiewicz, Jacek Woźniacka, Anna ISRN Endocrinol Clinical Study The hormonally active form of vitamin D(3), 1,25(OH)(2)D(3) (calcitriol), exerts actions through VDR receptor, which acts as a transcriptional factor. Calcitriol is an immunomodulator that affects various immune cells, and several studies link it to many autoimmune diseases. BsmI polymorphism affects the level of VDR gene transcription, transcript stability, and posttranscriptional modifications. It seems to be related to the systemic lupus erythematosus (SLE). Our study examined the characteristics of VDR gene BsmI polymorphism in Polish SLE patients and their relationship with clinical manifestations of the disease. We genotyped 62 patients with SLE and 100 healthy controls using the real-time PCR. There were no differences observed in the frequency of BsmI genotypes in SLE patients and in the control group. There was no significant correlation between BsmI genotypes and clinical symptoms of SLE, but the AA genotype correlates with higher levels of antinuclear antibodies (ANA) in this group (r = 0.438; P = 0.002). A larger study examining BsmI and other VDR gene polymorphisms is needed. It may allow explaining differences in the clinical picture of the disease and choosing a personalized therapy. Hindawi Publishing Corporation 2013-06-18 /pmc/articles/PMC3703334/ /pubmed/23853726 http://dx.doi.org/10.1155/2013/427818 Text en Copyright © 2013 Beata Kaleta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Kaleta, Beata Bogaczewicz, Jarosław Robak, Ewa Sysa-Jędrzejowska, Anna Wrzosek, Małgorzata Szubierajska, Weronika Mróz, Piotr Łukaszkiewicz, Jacek Woźniacka, Anna Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus |
title | Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus |
title_full | Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus |
title_fullStr | Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus |
title_full_unstemmed | Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus |
title_short | Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus |
title_sort | vitamin d receptor gene bsmi polymorphism in polish patients with systemic lupus erythematosus |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703334/ https://www.ncbi.nlm.nih.gov/pubmed/23853726 http://dx.doi.org/10.1155/2013/427818 |
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