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Update on Anticytokine Treatment for Asthma

Current advances in the knowledge of asthma pathobiology suggest that anticytokine therapies can be potentially useful for the treatment of this complex and heterogeneous airway disease. Recent evidence is accumulating in support of the efficacy of anti-IL-4, anti-IL-5, and anti-IL-13 drugs. Therefo...

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Autores principales: Gallelli, Luca, Busceti, Maria Teresa, Vatrella, Alessandro, Maselli, Rosario, Pelaia, Girolamo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703384/
https://www.ncbi.nlm.nih.gov/pubmed/23853765
http://dx.doi.org/10.1155/2013/104315
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author Gallelli, Luca
Busceti, Maria Teresa
Vatrella, Alessandro
Maselli, Rosario
Pelaia, Girolamo
author_facet Gallelli, Luca
Busceti, Maria Teresa
Vatrella, Alessandro
Maselli, Rosario
Pelaia, Girolamo
author_sort Gallelli, Luca
collection PubMed
description Current advances in the knowledge of asthma pathobiology suggest that anticytokine therapies can be potentially useful for the treatment of this complex and heterogeneous airway disease. Recent evidence is accumulating in support of the efficacy of anti-IL-4, anti-IL-5, and anti-IL-13 drugs. Therefore, these new developments are now changing the global scenario of antiasthma therapies, especially with regard to more severe disease. Current findings referring to variability of individual therapeutic responses highlight that the different asthma subtypes need to be well characterized, in order to implement phenotype-targeted treatments which in the near future will hopefully be mainly based on cytokine-directed biologics.
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spelling pubmed-37033842013-07-12 Update on Anticytokine Treatment for Asthma Gallelli, Luca Busceti, Maria Teresa Vatrella, Alessandro Maselli, Rosario Pelaia, Girolamo Biomed Res Int Review Article Current advances in the knowledge of asthma pathobiology suggest that anticytokine therapies can be potentially useful for the treatment of this complex and heterogeneous airway disease. Recent evidence is accumulating in support of the efficacy of anti-IL-4, anti-IL-5, and anti-IL-13 drugs. Therefore, these new developments are now changing the global scenario of antiasthma therapies, especially with regard to more severe disease. Current findings referring to variability of individual therapeutic responses highlight that the different asthma subtypes need to be well characterized, in order to implement phenotype-targeted treatments which in the near future will hopefully be mainly based on cytokine-directed biologics. Hindawi Publishing Corporation 2013 2013-06-18 /pmc/articles/PMC3703384/ /pubmed/23853765 http://dx.doi.org/10.1155/2013/104315 Text en Copyright © 2013 Luca Gallelli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gallelli, Luca
Busceti, Maria Teresa
Vatrella, Alessandro
Maselli, Rosario
Pelaia, Girolamo
Update on Anticytokine Treatment for Asthma
title Update on Anticytokine Treatment for Asthma
title_full Update on Anticytokine Treatment for Asthma
title_fullStr Update on Anticytokine Treatment for Asthma
title_full_unstemmed Update on Anticytokine Treatment for Asthma
title_short Update on Anticytokine Treatment for Asthma
title_sort update on anticytokine treatment for asthma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703384/
https://www.ncbi.nlm.nih.gov/pubmed/23853765
http://dx.doi.org/10.1155/2013/104315
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