A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

Splicing of pre-mRNAs in eukaryotes is catalyzed by the spliceosome a large RNA–protein metalloenzyme. The catalytic center of the spliceosome involves a structure comprised of the U2 and U6 snRNAs and includes a metal bound by U6 snRNA. The precise architecture of the splicesome active site however...

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Detalles Bibliográficos
Autores principales: Schellenberg, Matthew J., Wu, Tao, Ritchie, Dustin B., Fica, Sebastian, Staley, Jonathan P., Atta, Karim A., LaPointe, Paul, MacMillan, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703396/
https://www.ncbi.nlm.nih.gov/pubmed/23686287
http://dx.doi.org/10.1038/nsmb.2556

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