BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector...

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Detalles Bibliográficos
Autores principales: Salcedo, Suzana P., Marchesini, María I., Degos, Clara, Terwagne, Matthieu, Von Bargen, Kristine, Lepidi, Hubert, Herrmann, Claudia K., Santos Lacerda, Thais L., Imbert, Paul R. C., Pierre, Philippe, Alexopoulou, Lena, Letesson, Jean-Jacques, Comerci, Diego J., Gorvel, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703528/
https://www.ncbi.nlm.nih.gov/pubmed/23847770
http://dx.doi.org/10.3389/fcimb.2013.00028

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