Cargando…
The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor
The gonadotropin-releasing hormone (GnRH) was originally isolated from the mammalian hypothalamus for its role as the primary regulator of reproductive function. Since its discovery, GnRH has also been shown to be located in non-hypothalamic tissues and is known to have diverse functions. Although t...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703583/ https://www.ncbi.nlm.nih.gov/pubmed/23847594 http://dx.doi.org/10.3389/fendo.2013.00083 |
_version_ | 1782275923164266496 |
---|---|
author | Larco, Darwin Omar Semsarzadeh, Nina Nashat Cho-Clark, Madelaine Mani, Shaila K. John Wu, T. |
author_facet | Larco, Darwin Omar Semsarzadeh, Nina Nashat Cho-Clark, Madelaine Mani, Shaila K. John Wu, T. |
author_sort | Larco, Darwin Omar |
collection | PubMed |
description | The gonadotropin-releasing hormone (GnRH) was originally isolated from the mammalian hypothalamus for its role as the primary regulator of reproductive function. Since its discovery, GnRH has also been shown to be located in non-hypothalamic tissues and is known to have diverse functions. Although the regulation of GnRH synthesis and release has been extensively studied, there is additional evidence to suggest that the processing of GnRH to the metabolite GnRH-(1-5) represents another layer of regulation. The focus of this review will be on the current evidence for the action of the pentapeptide metabolite GnRH-(1-5) in regulating cellular migration. We discuss the potential role of GnRH-(1-5) in regulating GnRH neuronal migration during development. Furthermore, we demonstrate these actions are mediated by the activation of a G protein-coupled receptor. Our findings suggest that GnRH-(1-5) may play a developmental function in addition to regulating developing cells. |
format | Online Article Text |
id | pubmed-3703583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37035832013-07-11 The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor Larco, Darwin Omar Semsarzadeh, Nina Nashat Cho-Clark, Madelaine Mani, Shaila K. John Wu, T. Front Endocrinol (Lausanne) Endocrinology The gonadotropin-releasing hormone (GnRH) was originally isolated from the mammalian hypothalamus for its role as the primary regulator of reproductive function. Since its discovery, GnRH has also been shown to be located in non-hypothalamic tissues and is known to have diverse functions. Although the regulation of GnRH synthesis and release has been extensively studied, there is additional evidence to suggest that the processing of GnRH to the metabolite GnRH-(1-5) represents another layer of regulation. The focus of this review will be on the current evidence for the action of the pentapeptide metabolite GnRH-(1-5) in regulating cellular migration. We discuss the potential role of GnRH-(1-5) in regulating GnRH neuronal migration during development. Furthermore, we demonstrate these actions are mediated by the activation of a G protein-coupled receptor. Our findings suggest that GnRH-(1-5) may play a developmental function in addition to regulating developing cells. Frontiers Media S.A. 2013-07-08 /pmc/articles/PMC3703583/ /pubmed/23847594 http://dx.doi.org/10.3389/fendo.2013.00083 Text en Copyright © 2013 Larco, Semsarzadeh, Cho-Clark, Mani and Wu. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Endocrinology Larco, Darwin Omar Semsarzadeh, Nina Nashat Cho-Clark, Madelaine Mani, Shaila K. John Wu, T. The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor |
title | The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor |
title_full | The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor |
title_fullStr | The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor |
title_full_unstemmed | The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor |
title_short | The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor |
title_sort | novel actions of the metabolite gnrh-(1-5) are mediated by a g protein-coupled receptor |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703583/ https://www.ncbi.nlm.nih.gov/pubmed/23847594 http://dx.doi.org/10.3389/fendo.2013.00083 |
work_keys_str_mv | AT larcodarwinomar thenovelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT semsarzadehninanashat thenovelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT choclarkmadelaine thenovelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT manishailak thenovelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT johnwut thenovelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT larcodarwinomar novelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT semsarzadehninanashat novelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT choclarkmadelaine novelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT manishailak novelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor AT johnwut novelactionsofthemetabolitegnrh15aremediatedbyagproteincoupledreceptor |