Cargando…

Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment

Interleukin-1 (IL-1) is a major “alarm” upstream pro-inflammatory cytokine that also affects immunity and hematopoiesis by inducing cytokine cascades. In the tumor arena, IL-1 is produced by malignant or microenvironmental cells. As a pleiotropic cytokine, IL-1 is involved in tumorigenesis and tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Voronov, Elena, Dotan, Shahar, Krelin, Yakov, Song, Xiaoping, Elkabets, Moshe, Carmi, Yaron, Rider, Peleg, Idan Cohen, Romzova, Marianna, Kaplanov, Irena, Apte, Ron N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703603/ https://www.ncbi.nlm.nih.gov/pubmed/23847618 http://dx.doi.org/10.3389/fimmu.2013.00177

Ejemplares similares

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells
por: Rider, Peleg, et al.
Publicado: (2012)

The role IL-1 in tumor-mediated angiogenesis
por: Voronov, Elena, et al.
Publicado: (2014)

Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations
por: Rider, Peleg, et al.
Publicado: (2016)

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
por: Idan, Cohen, et al.
Publicado: (2015)

Modification of topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors
por: Peleg, Refael, et al.
Publicado: (2014)

Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity
por: Cohen, Idan, et al.
Publicado: (2016)

Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling
por: Beltrami-Moreira, Marina, et al.
Publicado: (2016)

Complementarity and redundancy of IL-22-producing innate lymphoid cells
por: Rankin, Lucille C., et al.
Publicado: (2015)

T Cells Expressing a Modified FcγRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors
por: Rasoulouniriana, Diana, et al.
Publicado: (2023)

Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide
por: Pittala, Srinivas, et al.
Publicado: (2018)

VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress
por: Shoshan-Barmatz, Varda, et al.
Publicado: (2017)

Worldwide Prevalence and Clinical Characteristics of RAS Mutations in Head and Neck Cancer: A Systematic Review and Meta-Analysis
por: Novoplansky, Ofra, et al.
Publicado: (2022)

Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
por: Shoshan-Barmatz, Varda, et al.
Publicado: (2017)

The role of cytokines in seizures: interleukin (IL)-1β, IL-1Ra, IL-8, and IL-10
por: Youn, Youngah, et al.
Publicado: (2013)

Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
por: Neves, Fabiana, et al.
Publicado: (2015)

IL-2 Suppression of IL-12p70 by a Recombinant HSV-1 Expressing IL-2 Induces T-Cell Auto-Reactivity and CNS Demyelination
por: Zandian, Mandana, et al.
Publicado: (2011)

Effects of carbon nanotubes on intercellular communication and involvement of IL-1 genes
por: Arnoldussen, Yke Jildouw, et al.
Publicado: (2016)

Relationship of redundant Th17 cells and IL-17A, but not IL-17 F, with the severity of obstructive sleep apnoea/hypopnoea syndrome (OSAHS)
por: Ying, Lin, et al.
Publicado: (2014)

IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection
por: Harker, James A., et al.
Publicado: (2023)

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity
por: Ottolenghi, Aner, et al.
Publicado: (2021)

Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and Expandability
por: Nov, Ori, et al.
Publicado: (2013)

Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation
por: Gubernatorova, Ekaterina O., et al.
Publicado: (2018)

Comparative Roles of IL-1, IL-6, IL-10, IL-17, IL-18, 1L-22, IL-33, and IL-37 in Various Cardiovascular Diseases With Potential Insights for Targeted Immunotherapy
por: Abubakar, Muhammad, et al.
Publicado: (2023)

Digital PCR can provide improved BCR-ABL1 detection in chronic myeloid leukemia patients in deep molecular response and sensitivity of standard quantitative methods using EAC assays
por: Smitalova, Dagmar, et al.
Publicado: (2021)

Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated States
por: Arif, Tasleem, et al.
Publicado: (2018)

Association of IL33, IL1RL1, IL1RAP Polymorphisms and Asthma in Chinese Han Children
por: Wu, Maolan, et al.
Publicado: (2021)

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
por: Eto, Danelle, et al.
Publicado: (2011)

A Brief History of IL-1 and IL-1 Ra in Rheumatology
por: Dayer, Jean-Michel, et al.
Publicado: (2017)

IL-1/IL-1R Signaling in Head and Neck Cancer
por: Niklander, Sven E., et al.
Publicado: (2021)

Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8(+) T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
por: Kim, Dong Hyun, et al.
Publicado: (2021)

Genetic models reveal origin, persistence and non-redundant functions of IL-17–producing γδ T cells
por: Sandrock, Inga, et al.
Publicado: (2018)

Commensal Bacteria and MAMPs Are Necessary for Stress-Induced Increases in IL-1β and IL-18 but Not IL-6, IL-10 or MCP-1
por: Maslanik, Thomas, et al.
Publicado: (2012)

IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections.
por: Basso, Beatriz, et al.
Publicado: (2005)

IL-1 and IL-4 as reciprocal regulators of IL-2 induced lymphocyte cytotoxicity.
por: Ebina, N., et al.
Publicado: (1990)

Intracellular IL-1Ra exhibits unique antiinflammatory properties
por: Arend, WP, et al.
Publicado: (2004)

The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters
por: Maculewicz, Ewelina, et al.
Publicado: (2022)

Gene Expression and Drug Sensitivity Analysis of Mitochondrial Chaperones Reveals That HSPD1 and TRAP1 Expression Correlates with Sensitivity to Inhibitors of DNA Replication and Mitosis
por: Badarni, Mai, et al.
Publicado: (2023)

Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
por: Lin, Emily, et al.
Publicado: (2019)

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease
por: Supino, Domenico, et al.
Publicado: (2022)

IL-1 Superfamily Member (IL-1A, IL-1B and IL-18) Genetic Variants Influence Susceptibility and Clinical Course of Mediterranean Spotter Fever
por: Scola, Letizia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sq6fi24ffeq6f92ivkaje5l80u