In Silico Screening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

Oculocutaneous albinism type III (OCA3), caused by mutations of TYRP1 gene, is an autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in the hair, skin, and eyes. The TYRP1 gene encodes a protein called tyrosinase-related protein-1 (Tyrp1). Tyrp1 is involved in main...

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Detalles Bibliográficos
Autores principales: Kamaraj, Balu, Purohit, Rituraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703794/
https://www.ncbi.nlm.nih.gov/pubmed/23862152
http://dx.doi.org/10.1155/2013/697051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703794/
https://www.ncbi.nlm.nih.gov/pubmed/23862152
http://dx.doi.org/10.1155/2013/697051

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