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CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444(C) risk allele is associated with greater cell surface expression of CD33 in monocytes (t(50) = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) dimini...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/ https://www.ncbi.nlm.nih.gov/pubmed/23708142 http://dx.doi.org/10.1038/nn.3435 |
| _version_ | 1782275950972502016 |
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| author | Bradshaw, Elizabeth M Chibnik, Lori B Keenan, Brendan T Ottoboni, Linda Raj, Towfique Tang, Anna Rosenkrantz, Laura L Imboywa, Selina Lee, Michelle Von Korff, Alina Morris, Martha C Evans, Denis A Johnson, Keith Sperling, Reisa A Schneider, Julie A Bennett, David A De Jager, Philip L |
| author_facet | Bradshaw, Elizabeth M Chibnik, Lori B Keenan, Brendan T Ottoboni, Linda Raj, Towfique Tang, Anna Rosenkrantz, Laura L Imboywa, Selina Lee, Michelle Von Korff, Alina Morris, Martha C Evans, Denis A Johnson, Keith Sperling, Reisa A Schneider, Julie A Bennett, David A De Jager, Philip L |
| author_sort | Bradshaw, Elizabeth M |
| collection | PubMed |
| description | In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444(C) risk allele is associated with greater cell surface expression of CD33 in monocytes (t(50) = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia. |
| format | Online Article Text |
| id | pubmed-3703870 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37038702014-01-01 CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology Bradshaw, Elizabeth M Chibnik, Lori B Keenan, Brendan T Ottoboni, Linda Raj, Towfique Tang, Anna Rosenkrantz, Laura L Imboywa, Selina Lee, Michelle Von Korff, Alina Morris, Martha C Evans, Denis A Johnson, Keith Sperling, Reisa A Schneider, Julie A Bennett, David A De Jager, Philip L Nat Neurosci Article In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444(C) risk allele is associated with greater cell surface expression of CD33 in monocytes (t(50) = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia. 2013-05-23 2013-07 /pmc/articles/PMC3703870/ /pubmed/23708142 http://dx.doi.org/10.1038/nn.3435 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Bradshaw, Elizabeth M Chibnik, Lori B Keenan, Brendan T Ottoboni, Linda Raj, Towfique Tang, Anna Rosenkrantz, Laura L Imboywa, Selina Lee, Michelle Von Korff, Alina Morris, Martha C Evans, Denis A Johnson, Keith Sperling, Reisa A Schneider, Julie A Bennett, David A De Jager, Philip L CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology |
| title | CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology |
| title_full | CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology |
| title_fullStr | CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology |
| title_full_unstemmed | CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology |
| title_short | CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology |
| title_sort | cd33 alzheimer’s disease locus: altered monocyte function and amyloid biology |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/ https://www.ncbi.nlm.nih.gov/pubmed/23708142 http://dx.doi.org/10.1038/nn.3435 |
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