Cargando…

Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells

Hematological malignancies frequently have a poor prognosis and often remain incurable. Drug resistance, severe side effects, and relapse are major problems of currently used drugs, and new candidate compounds are required for improvement of therapy success. The naphthoquinone shikonin derived from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiench, Benjamin, Chen, Yet-Ran, Paulsen, Malte, Hamm, Rebecca, Schröder, Sven, Yang, Ning-Sun, Efferth, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703888/ https://www.ncbi.nlm.nih.gov/pubmed/23861714 http://dx.doi.org/10.1155/2013/818709

Ejemplares similares

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
por: Wiench, Benjamin, et al.
Publicado: (2012)

Shikonin Inhibits Cell Growth of Sunitinib-Resistant Renal Cell Carcinoma by Activating the Necrosome Complex and Inhibiting the AKT/mTOR Signaling Pathway
por: Markowitsch, Sascha D., et al.
Publicado: (2022)

β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: LU, DAN, et al.
Publicado: (2015)

β-Hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: Lu, Dan, et al.
Publicado: (2021)

Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin
por: Ni, Fan, et al.
Publicado: (2018)

The Effects of Exogenous Lactate Administration on the IGF1/Akt/mTOR Pathway in Rat Skeletal Muscle
por: Kyun, Sunghwan, et al.
Publicado: (2020)

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer
por: De Martino, Maria Cristina, et al.
Publicado: (2019)

Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade
por: Maiese, Kenneth, et al.
Publicado: (2012)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices
por: Walz, Michael, et al.
Publicado: (2021)

Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
por: Yin, Shu-Yi, et al.
Publicado: (2016)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells via modulating miR-106b/PTEN/AKT/mTOR signaling pathway
por: Huang, Caimei, et al.
Publicado: (2018)

Correction: Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
por: Yin, Shu-Yi, et al.
Publicado: (2018)

Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine
por: Kuete, Victor, et al.
Publicado: (2013)

mTOR Signaling Cascade in Psoriatic Disease: Double Kinase mTOR Inhibitor a Novel Therapeutic Target
por: Raychaudhuri, Smriti K, et al.
Publicado: (2014)

IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
por: Erbay, Ebru, et al.
Publicado: (2003)

IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR
por: Littlejohn, Erica L., et al.
Publicado: (2021)

Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade
por: Rivera Rivera, Amilcar, et al.
Publicado: (2016)

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade
por: Tang, Bufu, et al.
Publicado: (2022)

Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin Disorders
por: Mercurio, Laura, et al.
Publicado: (2021)

IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling
por: García-Mato, Ángela, et al.
Publicado: (2023)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

Cytotoxicity and Modes of Action of the Methanol Extracts of Six Cameroonian Medicinal Plants against Multidrug-Resistant Tumor Cells
por: Kuete, Victor, et al.
Publicado: (2013)

Shikonin Promotes Apoptosis and Attenuates Migration and Invasion of Human Esophageal Cancer Cells by Inhibiting Tumor Necrosis Factor Receptor-Associated Protein 1 Expression and AKT/mTOR Signaling Pathway
por: Huang, Jingrong, et al.
Publicado: (2021)

The Cytotoxic Effect of Curcumin in Rhabdomyosarcoma Is Associated with the Modulation of AMPK, AKT/mTOR, STAT, and p53 Signaling
por: Salucci, Sara, et al.
Publicado: (2023)

Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
por: Kuete, Victor, et al.
Publicado: (2012)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway
por: YIN, Lijun, et al.
Publicado: (2020)

SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
por: Wang, Shaoqiang, et al.
Publicado: (2018)

Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
por: Yang, Min Hee, et al.
Publicado: (2019)

Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation
por: Wang, Juan, et al.
Publicado: (2022)

Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition
por: Leroy, Cedric, et al.
Publicado: (2016)

Nutmeg Extract Increases Skeletal Muscle Mass in Aging Rats Partly via IGF1-AKT-mTOR Pathway and Inhibition of Autophagy
por: Pratiwi, Yuni Susanti, et al.
Publicado: (2018)

CD26 upregulates proliferation and invasion in keloid fibroblasts through an IGF-1-induced PI3K/AKT/mTOR pathway
por: Xin, Yu, et al.
Publicado: (2020)

CircDiaph3 influences PASMC apoptosis by regulating PI3K/AKT/mTOR pathway through IGF1R
por: Liu, Ge, et al.
Publicado: (2023)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
por: McCubrey, James A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ok0jvt36p0n57bgqdeq33qtrf3