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Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells

Hematological malignancies frequently have a poor prognosis and often remain incurable. Drug resistance, severe side effects, and relapse are major problems of currently used drugs, and new candidate compounds are required for improvement of therapy success. The naphthoquinone shikonin derived from...

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Detalles Bibliográficos
Autores principales:	Wiench, Benjamin, Chen, Yet-Ran, Paulsen, Malte, Hamm, Rebecca, Schröder, Sven, Yang, Ning-Sun, Efferth, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703888/ https://www.ncbi.nlm.nih.gov/pubmed/23861714 http://dx.doi.org/10.1155/2013/818709

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