Cargando…
Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis
Objective. To investigate the association of serum sTREM-1 with myocardial dysfunction in patients with severe sepsis. Methods. A total of 85 patients with severe sepsis were divided into severe sepsis group (n = 40) and septic shock group (n = 45). Serum levels of sTREM-1, NT-proBNP, APACHE II scor...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703897/ https://www.ncbi.nlm.nih.gov/pubmed/23861562 http://dx.doi.org/10.1155/2013/819246 |
_version_ | 1782275954173804544 |
---|---|
author | Tao, Fei Peng, Liangshan Li, Juan Shao, Yiming Deng, Liehua Yao, Huaguo |
author_facet | Tao, Fei Peng, Liangshan Li, Juan Shao, Yiming Deng, Liehua Yao, Huaguo |
author_sort | Tao, Fei |
collection | PubMed |
description | Objective. To investigate the association of serum sTREM-1 with myocardial dysfunction in patients with severe sepsis. Methods. A total of 85 patients with severe sepsis were divided into severe sepsis group (n = 40) and septic shock group (n = 45). Serum levels of sTREM-1, NT-proBNP, APACHE II score, SOFA score, cardiac index, cardiac function index, global ejection fraction, and left ventricular contractility index were measured on days 1, 3, and 7 after admission to ICU. Results. Serum sTREM-1 levels of patients with septic shock were significantly higher than those with severe sepsis on days 1, 3, and 7. Serum sTREM-1 was positively correlated with APACHE II scores, SOFA scores, and NT-proBNP. However, The sTREM-1 level was markedly negatively correlated with CI, CFI, GEF, and dP/dt max, respectively. Multiple logistic regression analysis showed that sTREM-1 was independent risk factor to NT-proBNP increasing. The optimal cut-off point of sTREM-1 for detecting patients with myocardial dysfunction was 468.05 ng/mL with sensitivity (80.6%) and specificity (75.7%). There is no difference in TREM-1-mRNA expression between the two groups. Conclusions. Serum sTREM-1 is significantly associated with myocardial dysfunction and may be a valuable tool for determining the presence of myocardial dysfunction in patients with severe sepsis. |
format | Online Article Text |
id | pubmed-3703897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37038972013-07-16 Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis Tao, Fei Peng, Liangshan Li, Juan Shao, Yiming Deng, Liehua Yao, Huaguo Mediators Inflamm Research Article Objective. To investigate the association of serum sTREM-1 with myocardial dysfunction in patients with severe sepsis. Methods. A total of 85 patients with severe sepsis were divided into severe sepsis group (n = 40) and septic shock group (n = 45). Serum levels of sTREM-1, NT-proBNP, APACHE II score, SOFA score, cardiac index, cardiac function index, global ejection fraction, and left ventricular contractility index were measured on days 1, 3, and 7 after admission to ICU. Results. Serum sTREM-1 levels of patients with septic shock were significantly higher than those with severe sepsis on days 1, 3, and 7. Serum sTREM-1 was positively correlated with APACHE II scores, SOFA scores, and NT-proBNP. However, The sTREM-1 level was markedly negatively correlated with CI, CFI, GEF, and dP/dt max, respectively. Multiple logistic regression analysis showed that sTREM-1 was independent risk factor to NT-proBNP increasing. The optimal cut-off point of sTREM-1 for detecting patients with myocardial dysfunction was 468.05 ng/mL with sensitivity (80.6%) and specificity (75.7%). There is no difference in TREM-1-mRNA expression between the two groups. Conclusions. Serum sTREM-1 is significantly associated with myocardial dysfunction and may be a valuable tool for determining the presence of myocardial dysfunction in patients with severe sepsis. Hindawi Publishing Corporation 2013 2013-06-18 /pmc/articles/PMC3703897/ /pubmed/23861562 http://dx.doi.org/10.1155/2013/819246 Text en Copyright © 2013 Fei Tao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tao, Fei Peng, Liangshan Li, Juan Shao, Yiming Deng, Liehua Yao, Huaguo Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis |
title | Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis |
title_full | Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis |
title_fullStr | Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis |
title_full_unstemmed | Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis |
title_short | Association of Serum Myeloid Cells of Soluble Triggering Receptor-1 Level with Myocardial Dysfunction in Patients with Severe Sepsis |
title_sort | association of serum myeloid cells of soluble triggering receptor-1 level with myocardial dysfunction in patients with severe sepsis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703897/ https://www.ncbi.nlm.nih.gov/pubmed/23861562 http://dx.doi.org/10.1155/2013/819246 |
work_keys_str_mv | AT taofei associationofserummyeloidcellsofsolubletriggeringreceptor1levelwithmyocardialdysfunctioninpatientswithseveresepsis AT pengliangshan associationofserummyeloidcellsofsolubletriggeringreceptor1levelwithmyocardialdysfunctioninpatientswithseveresepsis AT lijuan associationofserummyeloidcellsofsolubletriggeringreceptor1levelwithmyocardialdysfunctioninpatientswithseveresepsis AT shaoyiming associationofserummyeloidcellsofsolubletriggeringreceptor1levelwithmyocardialdysfunctioninpatientswithseveresepsis AT dengliehua associationofserummyeloidcellsofsolubletriggeringreceptor1levelwithmyocardialdysfunctioninpatientswithseveresepsis AT yaohuaguo associationofserummyeloidcellsofsolubletriggeringreceptor1levelwithmyocardialdysfunctioninpatientswithseveresepsis |