Cargando…

Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions

A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation ta...

Descripción completa

Detalles Bibliográficos
Autores principales: Mesquita, Rickson C., Schenkel, Steven S., Minkoff, David L., Lu, Xiangping, Favilla, Christopher G., Vora, Patrick M., Busch, David R., Chandra, Malavika, Greenberg, Joel H., Detre, John A., Yodh, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704102/
https://www.ncbi.nlm.nih.gov/pubmed/23847725
http://dx.doi.org/10.1364/BOE.4.000978
_version_ 1782275964402663424
author Mesquita, Rickson C.
Schenkel, Steven S.
Minkoff, David L.
Lu, Xiangping
Favilla, Christopher G.
Vora, Patrick M.
Busch, David R.
Chandra, Malavika
Greenberg, Joel H.
Detre, John A.
Yodh, A. G.
author_facet Mesquita, Rickson C.
Schenkel, Steven S.
Minkoff, David L.
Lu, Xiangping
Favilla, Christopher G.
Vora, Patrick M.
Busch, David R.
Chandra, Malavika
Greenberg, Joel H.
Detre, John A.
Yodh, A. G.
author_sort Mesquita, Rickson C.
collection PubMed
description A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.
format Online
Article
Text
id pubmed-3704102
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Optical Society of America
record_format MEDLINE/PubMed
spelling pubmed-37041022013-07-11 Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions Mesquita, Rickson C. Schenkel, Steven S. Minkoff, David L. Lu, Xiangping Favilla, Christopher G. Vora, Patrick M. Busch, David R. Chandra, Malavika Greenberg, Joel H. Detre, John A. Yodh, A. G. Biomed Opt Express Optics of Tissue and Turbid Media A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues. Optical Society of America 2013-06-03 /pmc/articles/PMC3704102/ /pubmed/23847725 http://dx.doi.org/10.1364/BOE.4.000978 Text en ©2013 Optical Society of America author-open
spellingShingle Optics of Tissue and Turbid Media
Mesquita, Rickson C.
Schenkel, Steven S.
Minkoff, David L.
Lu, Xiangping
Favilla, Christopher G.
Vora, Patrick M.
Busch, David R.
Chandra, Malavika
Greenberg, Joel H.
Detre, John A.
Yodh, A. G.
Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
title Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
title_full Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
title_fullStr Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
title_full_unstemmed Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
title_short Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
title_sort influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
topic Optics of Tissue and Turbid Media
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704102/
https://www.ncbi.nlm.nih.gov/pubmed/23847725
http://dx.doi.org/10.1364/BOE.4.000978
work_keys_str_mv AT mesquitaricksonc influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT schenkelstevens influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT minkoffdavidl influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT luxiangping influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT favillachristopherg influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT vorapatrickm influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT buschdavidr influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT chandramalavika influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT greenbergjoelh influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT detrejohna influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions
AT yodhag influenceofprobepressureonthediffusecorrelationspectroscopybloodflowsignalextracerebralcontributions