Cargando…
Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
The nematode exoskeleton, commonly called the cuticle, is a highly structured extracellular matrix mainly composed of collagen. Secreted collagen molecules from the underlying epidermal cells are cross-linked via their tyrosyl residues. Reactive oxygen species (ROS) are required for the cross-linkin...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704445/ https://www.ncbi.nlm.nih.gov/pubmed/24058871 http://dx.doi.org/10.4161/worm.23415 |
_version_ | 1782276013911179264 |
---|---|
author | Moribe, Hiroki Mekada, Eisuke |
author_facet | Moribe, Hiroki Mekada, Eisuke |
author_sort | Moribe, Hiroki |
collection | PubMed |
description | The nematode exoskeleton, commonly called the cuticle, is a highly structured extracellular matrix mainly composed of collagen. Secreted collagen molecules from the underlying epidermal cells are cross-linked via their tyrosyl residues. Reactive oxygen species (ROS) are required for the cross-linking reaction to produce tyrosyl radicals. The conserved ROS generator enzyme in C. elegans, BLI-3/CeDUOX1, a homolog of dual oxidases (DUOXs), is responsible for production of hydrogen peroxide. The ROS generation system must be properly controlled since ROS are highly reactive molecules that irreversibly inhibit the functions of cellular components such as nucleic acids and proteins. We recently reported that the ROS generation system directed by BLI-3 requires the tetraspanin protein, TSP-15. Herein we outline the process of cuticle development with a focus on the molecular roles of TSP-15 in the BLI-3 system. We also propose the co-occurrence of tetraspanin and ROS generators by convergent evolution. |
format | Online Article Text |
id | pubmed-3704445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-37044452013-09-19 Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes Moribe, Hiroki Mekada, Eisuke Worm Commentary The nematode exoskeleton, commonly called the cuticle, is a highly structured extracellular matrix mainly composed of collagen. Secreted collagen molecules from the underlying epidermal cells are cross-linked via their tyrosyl residues. Reactive oxygen species (ROS) are required for the cross-linking reaction to produce tyrosyl radicals. The conserved ROS generator enzyme in C. elegans, BLI-3/CeDUOX1, a homolog of dual oxidases (DUOXs), is responsible for production of hydrogen peroxide. The ROS generation system must be properly controlled since ROS are highly reactive molecules that irreversibly inhibit the functions of cellular components such as nucleic acids and proteins. We recently reported that the ROS generation system directed by BLI-3 requires the tetraspanin protein, TSP-15. Herein we outline the process of cuticle development with a focus on the molecular roles of TSP-15 in the BLI-3 system. We also propose the co-occurrence of tetraspanin and ROS generators by convergent evolution. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3704445/ /pubmed/24058871 http://dx.doi.org/10.4161/worm.23415 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Moribe, Hiroki Mekada, Eisuke Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes |
title | Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes |
title_full | Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes |
title_fullStr | Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes |
title_full_unstemmed | Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes |
title_short | Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes |
title_sort | co-occurrence of tetraspanin and ros generators: conservation in protein cross-linking and other developmental processes |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704445/ https://www.ncbi.nlm.nih.gov/pubmed/24058871 http://dx.doi.org/10.4161/worm.23415 |
work_keys_str_mv | AT moribehiroki cooccurrenceoftetraspaninandrosgeneratorsconservationinproteincrosslinkingandotherdevelopmentalprocesses AT mekadaeisuke cooccurrenceoftetraspaninandrosgeneratorsconservationinproteincrosslinkingandotherdevelopmentalprocesses |