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Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes

The nematode exoskeleton, commonly called the cuticle, is a highly structured extracellular matrix mainly composed of collagen. Secreted collagen molecules from the underlying epidermal cells are cross-linked via their tyrosyl residues. Reactive oxygen species (ROS) are required for the cross-linkin...

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Autores principales: Moribe, Hiroki, Mekada, Eisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704445/
https://www.ncbi.nlm.nih.gov/pubmed/24058871
http://dx.doi.org/10.4161/worm.23415
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author Moribe, Hiroki
Mekada, Eisuke
author_facet Moribe, Hiroki
Mekada, Eisuke
author_sort Moribe, Hiroki
collection PubMed
description The nematode exoskeleton, commonly called the cuticle, is a highly structured extracellular matrix mainly composed of collagen. Secreted collagen molecules from the underlying epidermal cells are cross-linked via their tyrosyl residues. Reactive oxygen species (ROS) are required for the cross-linking reaction to produce tyrosyl radicals. The conserved ROS generator enzyme in C. elegans, BLI-3/CeDUOX1, a homolog of dual oxidases (DUOXs), is responsible for production of hydrogen peroxide. The ROS generation system must be properly controlled since ROS are highly reactive molecules that irreversibly inhibit the functions of cellular components such as nucleic acids and proteins. We recently reported that the ROS generation system directed by BLI-3 requires the tetraspanin protein, TSP-15. Herein we outline the process of cuticle development with a focus on the molecular roles of TSP-15 in the BLI-3 system. We also propose the co-occurrence of tetraspanin and ROS generators by convergent evolution.
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spelling pubmed-37044452013-09-19 Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes Moribe, Hiroki Mekada, Eisuke Worm Commentary The nematode exoskeleton, commonly called the cuticle, is a highly structured extracellular matrix mainly composed of collagen. Secreted collagen molecules from the underlying epidermal cells are cross-linked via their tyrosyl residues. Reactive oxygen species (ROS) are required for the cross-linking reaction to produce tyrosyl radicals. The conserved ROS generator enzyme in C. elegans, BLI-3/CeDUOX1, a homolog of dual oxidases (DUOXs), is responsible for production of hydrogen peroxide. The ROS generation system must be properly controlled since ROS are highly reactive molecules that irreversibly inhibit the functions of cellular components such as nucleic acids and proteins. We recently reported that the ROS generation system directed by BLI-3 requires the tetraspanin protein, TSP-15. Herein we outline the process of cuticle development with a focus on the molecular roles of TSP-15 in the BLI-3 system. We also propose the co-occurrence of tetraspanin and ROS generators by convergent evolution. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3704445/ /pubmed/24058871 http://dx.doi.org/10.4161/worm.23415 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Moribe, Hiroki
Mekada, Eisuke
Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
title Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
title_full Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
title_fullStr Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
title_full_unstemmed Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
title_short Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes
title_sort co-occurrence of tetraspanin and ros generators: conservation in protein cross-linking and other developmental processes
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704445/
https://www.ncbi.nlm.nih.gov/pubmed/24058871
http://dx.doi.org/10.4161/worm.23415
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