Cargando…
Ancient neuromodulation by vasopressin/oxytocin-related peptides
Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In verteb...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704447/ https://www.ncbi.nlm.nih.gov/pubmed/24058873 http://dx.doi.org/10.4161/worm.24246 |
_version_ | 1782276014395621376 |
---|---|
author | Beets, Isabel Temmerman, Liesbet Janssen, Tom Schoofs, Liliane |
author_facet | Beets, Isabel Temmerman, Liesbet Janssen, Tom Schoofs, Liliane |
author_sort | Beets, Isabel |
collection | PubMed |
description | Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In vertebrates, vasopressin and oxytocin have both hormonal effects on peripheral target tissues, such as in the regulation of reproduction and water balance, and neuromodulatory actions in the central nervous system controlling social behavior and cognition. The recent identification of vasopressin/oxytocin-related signaling in C. elegans reveals that this peptidergic system is widespread among nematodes. Genetic analysis of the C. elegans nematocin system denotes vasopressin/oxytocin-like peptides as ancient neuromodulators of neuronal circuits involved in reproductive behavior and associative learning, whereas former invertebrate studies focused on conserved peripheral actions of this peptide family. Nematocin provides neuromodulatory input into the gustatory plasticity circuit as well as into distinct male mating circuits to generate a coherent mating behavior. Molecular interactions are comparable to those underlying vasopressin- and oxytocin-mediated effects in the mammalian brain. Understanding how the vasopressin/oxytocin family fine-tunes neuronal circuits for social behavior, learning and memory poses a major challenge. Functional conservation of these effects in nematodes and most likely in other invertebrates enables the development of future models to help answering this question. |
format | Online Article Text |
id | pubmed-3704447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-37044472013-09-19 Ancient neuromodulation by vasopressin/oxytocin-related peptides Beets, Isabel Temmerman, Liesbet Janssen, Tom Schoofs, Liliane Worm Mini Review Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In vertebrates, vasopressin and oxytocin have both hormonal effects on peripheral target tissues, such as in the regulation of reproduction and water balance, and neuromodulatory actions in the central nervous system controlling social behavior and cognition. The recent identification of vasopressin/oxytocin-related signaling in C. elegans reveals that this peptidergic system is widespread among nematodes. Genetic analysis of the C. elegans nematocin system denotes vasopressin/oxytocin-like peptides as ancient neuromodulators of neuronal circuits involved in reproductive behavior and associative learning, whereas former invertebrate studies focused on conserved peripheral actions of this peptide family. Nematocin provides neuromodulatory input into the gustatory plasticity circuit as well as into distinct male mating circuits to generate a coherent mating behavior. Molecular interactions are comparable to those underlying vasopressin- and oxytocin-mediated effects in the mammalian brain. Understanding how the vasopressin/oxytocin family fine-tunes neuronal circuits for social behavior, learning and memory poses a major challenge. Functional conservation of these effects in nematodes and most likely in other invertebrates enables the development of future models to help answering this question. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3704447/ /pubmed/24058873 http://dx.doi.org/10.4161/worm.24246 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Mini Review Beets, Isabel Temmerman, Liesbet Janssen, Tom Schoofs, Liliane Ancient neuromodulation by vasopressin/oxytocin-related peptides |
title | Ancient neuromodulation by vasopressin/oxytocin-related peptides |
title_full | Ancient neuromodulation by vasopressin/oxytocin-related peptides |
title_fullStr | Ancient neuromodulation by vasopressin/oxytocin-related peptides |
title_full_unstemmed | Ancient neuromodulation by vasopressin/oxytocin-related peptides |
title_short | Ancient neuromodulation by vasopressin/oxytocin-related peptides |
title_sort | ancient neuromodulation by vasopressin/oxytocin-related peptides |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704447/ https://www.ncbi.nlm.nih.gov/pubmed/24058873 http://dx.doi.org/10.4161/worm.24246 |
work_keys_str_mv | AT beetsisabel ancientneuromodulationbyvasopressinoxytocinrelatedpeptides AT temmermanliesbet ancientneuromodulationbyvasopressinoxytocinrelatedpeptides AT janssentom ancientneuromodulationbyvasopressinoxytocinrelatedpeptides AT schoofsliliane ancientneuromodulationbyvasopressinoxytocinrelatedpeptides |