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Ancient neuromodulation by vasopressin/oxytocin-related peptides

Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In verteb...

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Autores principales: Beets, Isabel, Temmerman, Liesbet, Janssen, Tom, Schoofs, Liliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704447/
https://www.ncbi.nlm.nih.gov/pubmed/24058873
http://dx.doi.org/10.4161/worm.24246
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author Beets, Isabel
Temmerman, Liesbet
Janssen, Tom
Schoofs, Liliane
author_facet Beets, Isabel
Temmerman, Liesbet
Janssen, Tom
Schoofs, Liliane
author_sort Beets, Isabel
collection PubMed
description Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In vertebrates, vasopressin and oxytocin have both hormonal effects on peripheral target tissues, such as in the regulation of reproduction and water balance, and neuromodulatory actions in the central nervous system controlling social behavior and cognition. The recent identification of vasopressin/oxytocin-related signaling in C. elegans reveals that this peptidergic system is widespread among nematodes. Genetic analysis of the C. elegans nematocin system denotes vasopressin/oxytocin-like peptides as ancient neuromodulators of neuronal circuits involved in reproductive behavior and associative learning, whereas former invertebrate studies focused on conserved peripheral actions of this peptide family. Nematocin provides neuromodulatory input into the gustatory plasticity circuit as well as into distinct male mating circuits to generate a coherent mating behavior. Molecular interactions are comparable to those underlying vasopressin- and oxytocin-mediated effects in the mammalian brain. Understanding how the vasopressin/oxytocin family fine-tunes neuronal circuits for social behavior, learning and memory poses a major challenge. Functional conservation of these effects in nematodes and most likely in other invertebrates enables the development of future models to help answering this question.
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spelling pubmed-37044472013-09-19 Ancient neuromodulation by vasopressin/oxytocin-related peptides Beets, Isabel Temmerman, Liesbet Janssen, Tom Schoofs, Liliane Worm Mini Review Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In vertebrates, vasopressin and oxytocin have both hormonal effects on peripheral target tissues, such as in the regulation of reproduction and water balance, and neuromodulatory actions in the central nervous system controlling social behavior and cognition. The recent identification of vasopressin/oxytocin-related signaling in C. elegans reveals that this peptidergic system is widespread among nematodes. Genetic analysis of the C. elegans nematocin system denotes vasopressin/oxytocin-like peptides as ancient neuromodulators of neuronal circuits involved in reproductive behavior and associative learning, whereas former invertebrate studies focused on conserved peripheral actions of this peptide family. Nematocin provides neuromodulatory input into the gustatory plasticity circuit as well as into distinct male mating circuits to generate a coherent mating behavior. Molecular interactions are comparable to those underlying vasopressin- and oxytocin-mediated effects in the mammalian brain. Understanding how the vasopressin/oxytocin family fine-tunes neuronal circuits for social behavior, learning and memory poses a major challenge. Functional conservation of these effects in nematodes and most likely in other invertebrates enables the development of future models to help answering this question. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3704447/ /pubmed/24058873 http://dx.doi.org/10.4161/worm.24246 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Mini Review
Beets, Isabel
Temmerman, Liesbet
Janssen, Tom
Schoofs, Liliane
Ancient neuromodulation by vasopressin/oxytocin-related peptides
title Ancient neuromodulation by vasopressin/oxytocin-related peptides
title_full Ancient neuromodulation by vasopressin/oxytocin-related peptides
title_fullStr Ancient neuromodulation by vasopressin/oxytocin-related peptides
title_full_unstemmed Ancient neuromodulation by vasopressin/oxytocin-related peptides
title_short Ancient neuromodulation by vasopressin/oxytocin-related peptides
title_sort ancient neuromodulation by vasopressin/oxytocin-related peptides
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704447/
https://www.ncbi.nlm.nih.gov/pubmed/24058873
http://dx.doi.org/10.4161/worm.24246
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