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Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

The accumulation of aggregated mutant huntingtin (mHtt) inclusion bodies is involved in Huntigton’s disease (HD) progression. Medium sized-spiny neurons (MSNs) in the corpus striatum are highly vulnerable to mHtt aggregate accumulation and degeneration, but the mechanisms and pathways involved remai...

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Detalles Bibliográficos
Autores principales:	Proenca, Catia C., Stoehr, Natacha, Bernhard, Mario, Seger, Shanon, Genoud, Christel, Roscic, Ana, Paganetti, Paolo, Liu, Shanming, Murphy, Leon O., Kuhn, Rainer, Bouwmeester, Tewis, Galimberti, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704647/ https://www.ncbi.nlm.nih.gov/pubmed/23861892 http://dx.doi.org/10.1371/journal.pone.0068357

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