Big steps toward understanding dynein

Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Rec...

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Detalles Bibliográficos
Autor principal: Kikkawa, Masahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704981/
https://www.ncbi.nlm.nih.gov/pubmed/23836927
http://dx.doi.org/10.1083/jcb.201304099
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author Kikkawa, Masahide
author_facet Kikkawa, Masahide
author_sort Kikkawa, Masahide
collection PubMed
description Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Recent progress in understanding the force-generating mechanism of dynein using x-ray crystallography, cryo-electron microscopy, and single molecule studies has provided key insight into the structure and mechanism of action of this complex motor protein.
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spelling pubmed-37049812014-01-08 Big steps toward understanding dynein Kikkawa, Masahide J Cell Biol Reviews Dynein is a microtubule-based molecular motor that is involved in various biological functions, such as axonal transport, mitosis, and cilia/flagella movement. Although dynein was discovered 50 years ago, the progress of dynein research has been slow due to its large size and flexible structure. Recent progress in understanding the force-generating mechanism of dynein using x-ray crystallography, cryo-electron microscopy, and single molecule studies has provided key insight into the structure and mechanism of action of this complex motor protein. The Rockefeller University Press 2013-07-08 /pmc/articles/PMC3704981/ /pubmed/23836927 http://dx.doi.org/10.1083/jcb.201304099 Text en © 2013 Kikkawa This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Kikkawa, Masahide
Big steps toward understanding dynein
title Big steps toward understanding dynein
title_full Big steps toward understanding dynein
title_fullStr Big steps toward understanding dynein
title_full_unstemmed Big steps toward understanding dynein
title_short Big steps toward understanding dynein
title_sort big steps toward understanding dynein
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704981/
https://www.ncbi.nlm.nih.gov/pubmed/23836927
http://dx.doi.org/10.1083/jcb.201304099
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