Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

In migrating cells, integrin-based focal adhesions (FAs) assemble in protruding lamellipodia in association with rapid filamentous actin (F-actin) assembly and retrograde flow. How dynamic F-actin is coupled to FA is not known. We analyzed the role of vinculin in integrating F-actin and FA dynamics...

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Detalles Bibliográficos
Autores principales: Thievessen, Ingo, Thompson, Peter M., Berlemont, Sylvain, Plevock, Karen M., Plotnikov, Sergey V., Zemljic-Harpf, Alice, Ross, Robert S., Davidson, Michael W., Danuser, Gaudenz, Campbell, Sharon L., Waterman, Clare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704983/
https://www.ncbi.nlm.nih.gov/pubmed/23836933
http://dx.doi.org/10.1083/jcb.201303129

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