Probing the depths of cellular senescence

Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (201...

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Detalles Bibliográficos
Autores principales: Baker, Darren J., Sedivy, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704986/
https://www.ncbi.nlm.nih.gov/pubmed/23816622
http://dx.doi.org/10.1083/jcb.201305155
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author Baker, Darren J.
Sedivy, John M.
author_facet Baker, Darren J.
Sedivy, John M.
author_sort Baker, Darren J.
collection PubMed
description Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.
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spelling pubmed-37049862014-01-08 Probing the depths of cellular senescence Baker, Darren J. Sedivy, John M. J Cell Biol Reviews Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway. The Rockefeller University Press 2013-07-08 /pmc/articles/PMC3704986/ /pubmed/23816622 http://dx.doi.org/10.1083/jcb.201305155 Text en © 2013 Baker and Sedivy This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Baker, Darren J.
Sedivy, John M.
Probing the depths of cellular senescence
title Probing the depths of cellular senescence
title_full Probing the depths of cellular senescence
title_fullStr Probing the depths of cellular senescence
title_full_unstemmed Probing the depths of cellular senescence
title_short Probing the depths of cellular senescence
title_sort probing the depths of cellular senescence
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704986/
https://www.ncbi.nlm.nih.gov/pubmed/23816622
http://dx.doi.org/10.1083/jcb.201305155
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