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β-Catenin protects the epidermis from mechanical stresses

Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal dev...

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Detalles Bibliográficos
Autores principales: Ray, Samriddha, Foote, Henry P., Lechler, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704987/
https://www.ncbi.nlm.nih.gov/pubmed/23816618
http://dx.doi.org/10.1083/jcb.201212140
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author Ray, Samriddha
Foote, Henry P.
Lechler, Terry
author_facet Ray, Samriddha
Foote, Henry P.
Lechler, Terry
author_sort Ray, Samriddha
collection PubMed
description Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal development caused perinatal lethality. Mutant embryos up-regulated stress responses at sites of active morphogenesis, which became more widespread after the stresses associated with birth. In addition, selective loss of tight junctions occurred in focal regions. This was recapitulated in cultured β-catenin–null cells exposed to externally applied forces. In addition, mutant cells were defective in tension-induced engagement of adherens junctions. We found that β-catenin was required to recruit vinculin to the cell cortex and to strengthen the junction’s association with the underlying cytoskeleton in response to tension. These data demonstrate that a complete understanding of the functions of cell adhesion proteins must take into account their roles in response to mechanical stresses.
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spelling pubmed-37049872014-01-08 β-Catenin protects the epidermis from mechanical stresses Ray, Samriddha Foote, Henry P. Lechler, Terry J Cell Biol Research Articles Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal development caused perinatal lethality. Mutant embryos up-regulated stress responses at sites of active morphogenesis, which became more widespread after the stresses associated with birth. In addition, selective loss of tight junctions occurred in focal regions. This was recapitulated in cultured β-catenin–null cells exposed to externally applied forces. In addition, mutant cells were defective in tension-induced engagement of adherens junctions. We found that β-catenin was required to recruit vinculin to the cell cortex and to strengthen the junction’s association with the underlying cytoskeleton in response to tension. These data demonstrate that a complete understanding of the functions of cell adhesion proteins must take into account their roles in response to mechanical stresses. The Rockefeller University Press 2013-07-08 /pmc/articles/PMC3704987/ /pubmed/23816618 http://dx.doi.org/10.1083/jcb.201212140 Text en © 2013 Ray et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Research Articles
Ray, Samriddha
Foote, Henry P.
Lechler, Terry
β-Catenin protects the epidermis from mechanical stresses
title β-Catenin protects the epidermis from mechanical stresses
title_full β-Catenin protects the epidermis from mechanical stresses
title_fullStr β-Catenin protects the epidermis from mechanical stresses
title_full_unstemmed β-Catenin protects the epidermis from mechanical stresses
title_short β-Catenin protects the epidermis from mechanical stresses
title_sort β-catenin protects the epidermis from mechanical stresses
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704987/
https://www.ncbi.nlm.nih.gov/pubmed/23816618
http://dx.doi.org/10.1083/jcb.201212140
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