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β-Catenin protects the epidermis from mechanical stresses
Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal dev...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704987/ https://www.ncbi.nlm.nih.gov/pubmed/23816618 http://dx.doi.org/10.1083/jcb.201212140 |
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author | Ray, Samriddha Foote, Henry P. Lechler, Terry |
author_facet | Ray, Samriddha Foote, Henry P. Lechler, Terry |
author_sort | Ray, Samriddha |
collection | PubMed |
description | Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal development caused perinatal lethality. Mutant embryos up-regulated stress responses at sites of active morphogenesis, which became more widespread after the stresses associated with birth. In addition, selective loss of tight junctions occurred in focal regions. This was recapitulated in cultured β-catenin–null cells exposed to externally applied forces. In addition, mutant cells were defective in tension-induced engagement of adherens junctions. We found that β-catenin was required to recruit vinculin to the cell cortex and to strengthen the junction’s association with the underlying cytoskeleton in response to tension. These data demonstrate that a complete understanding of the functions of cell adhesion proteins must take into account their roles in response to mechanical stresses. |
format | Online Article Text |
id | pubmed-3704987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37049872014-01-08 β-Catenin protects the epidermis from mechanical stresses Ray, Samriddha Foote, Henry P. Lechler, Terry J Cell Biol Research Articles Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal development caused perinatal lethality. Mutant embryos up-regulated stress responses at sites of active morphogenesis, which became more widespread after the stresses associated with birth. In addition, selective loss of tight junctions occurred in focal regions. This was recapitulated in cultured β-catenin–null cells exposed to externally applied forces. In addition, mutant cells were defective in tension-induced engagement of adherens junctions. We found that β-catenin was required to recruit vinculin to the cell cortex and to strengthen the junction’s association with the underlying cytoskeleton in response to tension. These data demonstrate that a complete understanding of the functions of cell adhesion proteins must take into account their roles in response to mechanical stresses. The Rockefeller University Press 2013-07-08 /pmc/articles/PMC3704987/ /pubmed/23816618 http://dx.doi.org/10.1083/jcb.201212140 Text en © 2013 Ray et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Ray, Samriddha Foote, Henry P. Lechler, Terry β-Catenin protects the epidermis from mechanical stresses |
title | β-Catenin protects the epidermis from mechanical stresses |
title_full | β-Catenin protects the epidermis from mechanical stresses |
title_fullStr | β-Catenin protects the epidermis from mechanical stresses |
title_full_unstemmed | β-Catenin protects the epidermis from mechanical stresses |
title_short | β-Catenin protects the epidermis from mechanical stresses |
title_sort | β-catenin protects the epidermis from mechanical stresses |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704987/ https://www.ncbi.nlm.nih.gov/pubmed/23816618 http://dx.doi.org/10.1083/jcb.201212140 |
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