Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1

Little is known about how a neuron undergoes site-specific changes in intrinsic excitability during neuronal activity. We provide evidence for a novel mechanism for mTORC1 kinase–dependent translational regulation of the voltage-gated potassium channel Kv1.1 messenger RNA (mRNA). We identified a mic...

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Detalles Bibliográficos
Autores principales: Sosanya, Natasha M., Huang, Peggy P.C., Cacheaux, Luisa P., Chen, Chun Jung, Nguyen, Kathleen, Perrone-Bizzozero, Nora I., Raab-Graham, Kimberly F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704988/
https://www.ncbi.nlm.nih.gov/pubmed/23836929
http://dx.doi.org/10.1083/jcb.201212089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704988/
https://www.ncbi.nlm.nih.gov/pubmed/23836929
http://dx.doi.org/10.1083/jcb.201212089

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