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Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies

To study prevalence, specific patterns and response to treatment of tremor in dementia with Lewy bodies (DLB), in comparison with other tremulous disorders prevalence, qualitative and quantitative features of tremor were studied in an incident cohort of 67 dopaminergic treatment naive DLB, 111 Parki...

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Autores principales: Onofrj, Marco, Varanese, Sara, Bonanni, Laura, Taylor, John-Paul, Antonini, Angelo, Valente, Enza Maria, Petrucci, Simona, Stocchi, Fabrizio, Thomas, Astrid, Perfetti, Bernardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705145/
https://www.ncbi.nlm.nih.gov/pubmed/23400498
http://dx.doi.org/10.1007/s00415-013-6853-y
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author Onofrj, Marco
Varanese, Sara
Bonanni, Laura
Taylor, John-Paul
Antonini, Angelo
Valente, Enza Maria
Petrucci, Simona
Stocchi, Fabrizio
Thomas, Astrid
Perfetti, Bernardo
author_facet Onofrj, Marco
Varanese, Sara
Bonanni, Laura
Taylor, John-Paul
Antonini, Angelo
Valente, Enza Maria
Petrucci, Simona
Stocchi, Fabrizio
Thomas, Astrid
Perfetti, Bernardo
author_sort Onofrj, Marco
collection PubMed
description To study prevalence, specific patterns and response to treatment of tremor in dementia with Lewy bodies (DLB), in comparison with other tremulous disorders prevalence, qualitative and quantitative features of tremor were studied in an incident cohort of 67 dopaminergic treatment naive DLB, 111 Parkinson’s Disease (PD) and 34 Essential Tremor (ET) patients. Tremulous DLB patients (tDLB) were compared with tremulous PD (tPD) and ET patients and followed for 2 years. Double blind placebo-controlled acute drug challenge with l-Dopa and alcohol was performed in all ET, 24 tDLB and 27 tPD. Effects of dopaminergic chronic treatment in all tDLB and tPD patients and primidone in 8 tDLB were also assessed. Tremor occurred in 44.76 % of DLB patients. The tDLB patients presented a complex pattern of mixed tremors, characterized by rest and postural/action tremor, including walking tremor and standing overflow in 50 % tDLB. Standing tremor with overflow was characteristic of tDLB (p < 0.001). Head tremor was more frequent in tDLB than tPD and ET (p = 0.001). The tDLB tremors were reduced by acute and chronic dopaminergic treatments (p < 0.01) but not by alcohol or primidone. Tremor occurs commonly in DLB patients with a complex mixed tremor pattern which shows a significant response to acute and chronic dopaminergic treatments. Recognizing that there is a clinical category of tremulous DLB may help the differential diagnosis of tremors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00415-013-6853-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-37051452013-07-11 Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies Onofrj, Marco Varanese, Sara Bonanni, Laura Taylor, John-Paul Antonini, Angelo Valente, Enza Maria Petrucci, Simona Stocchi, Fabrizio Thomas, Astrid Perfetti, Bernardo J Neurol Original Communication To study prevalence, specific patterns and response to treatment of tremor in dementia with Lewy bodies (DLB), in comparison with other tremulous disorders prevalence, qualitative and quantitative features of tremor were studied in an incident cohort of 67 dopaminergic treatment naive DLB, 111 Parkinson’s Disease (PD) and 34 Essential Tremor (ET) patients. Tremulous DLB patients (tDLB) were compared with tremulous PD (tPD) and ET patients and followed for 2 years. Double blind placebo-controlled acute drug challenge with l-Dopa and alcohol was performed in all ET, 24 tDLB and 27 tPD. Effects of dopaminergic chronic treatment in all tDLB and tPD patients and primidone in 8 tDLB were also assessed. Tremor occurred in 44.76 % of DLB patients. The tDLB patients presented a complex pattern of mixed tremors, characterized by rest and postural/action tremor, including walking tremor and standing overflow in 50 % tDLB. Standing tremor with overflow was characteristic of tDLB (p < 0.001). Head tremor was more frequent in tDLB than tPD and ET (p = 0.001). The tDLB tremors were reduced by acute and chronic dopaminergic treatments (p < 0.01) but not by alcohol or primidone. Tremor occurs commonly in DLB patients with a complex mixed tremor pattern which shows a significant response to acute and chronic dopaminergic treatments. Recognizing that there is a clinical category of tremulous DLB may help the differential diagnosis of tremors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00415-013-6853-y) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2013-02-12 2013 /pmc/articles/PMC3705145/ /pubmed/23400498 http://dx.doi.org/10.1007/s00415-013-6853-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Communication
Onofrj, Marco
Varanese, Sara
Bonanni, Laura
Taylor, John-Paul
Antonini, Angelo
Valente, Enza Maria
Petrucci, Simona
Stocchi, Fabrizio
Thomas, Astrid
Perfetti, Bernardo
Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
title Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
title_full Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
title_fullStr Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
title_full_unstemmed Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
title_short Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
title_sort cohort study of prevalence and phenomenology of tremor in dementia with lewy bodies
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705145/
https://www.ncbi.nlm.nih.gov/pubmed/23400498
http://dx.doi.org/10.1007/s00415-013-6853-y
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