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Tick vaccines and the control of tick-borne pathogens

Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen intera...

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Autores principales: Merino, Octavio, Alberdi, Pilar, Pérez de la Lastra, José M., de la Fuente, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705209/
https://www.ncbi.nlm.nih.gov/pubmed/23847771
http://dx.doi.org/10.3389/fcimb.2013.00030
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author Merino, Octavio
Alberdi, Pilar
Pérez de la Lastra, José M.
de la Fuente, José
author_facet Merino, Octavio
Alberdi, Pilar
Pérez de la Lastra, José M.
de la Fuente, José
author_sort Merino, Octavio
collection PubMed
description Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen interactions. Advances in vector and pathogen genomics and proteomics have moved forward our knowledge of the vector-pathogen interactions that take place during the colonization and transmission of arthropod-borne microbes. Tick-borne pathogens adapt from the vector to the mammalian host by differential gene expression thus modulating host processes. In recent years, studies have shown that targeting tick proteins by vaccination can not only reduce tick feeding and reproduction, but also the infection and transmission of pathogens from the tick to the vertebrate host. In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens.
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spelling pubmed-37052092013-07-11 Tick vaccines and the control of tick-borne pathogens Merino, Octavio Alberdi, Pilar Pérez de la Lastra, José M. de la Fuente, José Front Cell Infect Microbiol Microbiology Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen interactions. Advances in vector and pathogen genomics and proteomics have moved forward our knowledge of the vector-pathogen interactions that take place during the colonization and transmission of arthropod-borne microbes. Tick-borne pathogens adapt from the vector to the mammalian host by differential gene expression thus modulating host processes. In recent years, studies have shown that targeting tick proteins by vaccination can not only reduce tick feeding and reproduction, but also the infection and transmission of pathogens from the tick to the vertebrate host. In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens. Frontiers Media S.A. 2013-07-09 /pmc/articles/PMC3705209/ /pubmed/23847771 http://dx.doi.org/10.3389/fcimb.2013.00030 Text en Copyright © 2013 Merino, Alberdi, Pérez de la Lastra and de la Fuente. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Microbiology
Merino, Octavio
Alberdi, Pilar
Pérez de la Lastra, José M.
de la Fuente, José
Tick vaccines and the control of tick-borne pathogens
title Tick vaccines and the control of tick-borne pathogens
title_full Tick vaccines and the control of tick-borne pathogens
title_fullStr Tick vaccines and the control of tick-borne pathogens
title_full_unstemmed Tick vaccines and the control of tick-borne pathogens
title_short Tick vaccines and the control of tick-borne pathogens
title_sort tick vaccines and the control of tick-borne pathogens
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705209/
https://www.ncbi.nlm.nih.gov/pubmed/23847771
http://dx.doi.org/10.3389/fcimb.2013.00030
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