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Tick vaccines and the control of tick-borne pathogens
Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen intera...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705209/ https://www.ncbi.nlm.nih.gov/pubmed/23847771 http://dx.doi.org/10.3389/fcimb.2013.00030 |
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author | Merino, Octavio Alberdi, Pilar Pérez de la Lastra, José M. de la Fuente, José |
author_facet | Merino, Octavio Alberdi, Pilar Pérez de la Lastra, José M. de la Fuente, José |
author_sort | Merino, Octavio |
collection | PubMed |
description | Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen interactions. Advances in vector and pathogen genomics and proteomics have moved forward our knowledge of the vector-pathogen interactions that take place during the colonization and transmission of arthropod-borne microbes. Tick-borne pathogens adapt from the vector to the mammalian host by differential gene expression thus modulating host processes. In recent years, studies have shown that targeting tick proteins by vaccination can not only reduce tick feeding and reproduction, but also the infection and transmission of pathogens from the tick to the vertebrate host. In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens. |
format | Online Article Text |
id | pubmed-3705209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37052092013-07-11 Tick vaccines and the control of tick-borne pathogens Merino, Octavio Alberdi, Pilar Pérez de la Lastra, José M. de la Fuente, José Front Cell Infect Microbiol Microbiology Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen interactions. Advances in vector and pathogen genomics and proteomics have moved forward our knowledge of the vector-pathogen interactions that take place during the colonization and transmission of arthropod-borne microbes. Tick-borne pathogens adapt from the vector to the mammalian host by differential gene expression thus modulating host processes. In recent years, studies have shown that targeting tick proteins by vaccination can not only reduce tick feeding and reproduction, but also the infection and transmission of pathogens from the tick to the vertebrate host. In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens. Frontiers Media S.A. 2013-07-09 /pmc/articles/PMC3705209/ /pubmed/23847771 http://dx.doi.org/10.3389/fcimb.2013.00030 Text en Copyright © 2013 Merino, Alberdi, Pérez de la Lastra and de la Fuente. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Microbiology Merino, Octavio Alberdi, Pilar Pérez de la Lastra, José M. de la Fuente, José Tick vaccines and the control of tick-borne pathogens |
title | Tick vaccines and the control of tick-borne pathogens |
title_full | Tick vaccines and the control of tick-borne pathogens |
title_fullStr | Tick vaccines and the control of tick-borne pathogens |
title_full_unstemmed | Tick vaccines and the control of tick-borne pathogens |
title_short | Tick vaccines and the control of tick-borne pathogens |
title_sort | tick vaccines and the control of tick-borne pathogens |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705209/ https://www.ncbi.nlm.nih.gov/pubmed/23847771 http://dx.doi.org/10.3389/fcimb.2013.00030 |
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