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Foamy Virus Budding and Release

Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction of the capsid protein with components of cellu...

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Autores principales: Hütter, Sylvia, Zurnic, Irena, Lindemann, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705266/
https://www.ncbi.nlm.nih.gov/pubmed/23575110
http://dx.doi.org/10.3390/v5041075
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author Hütter, Sylvia
Zurnic, Irena
Lindemann, Dirk
author_facet Hütter, Sylvia
Zurnic, Irena
Lindemann, Dirk
author_sort Hütter, Sylvia
collection PubMed
description Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction of the capsid protein with components of cellular vacuolar protein sorting (Vps) machinery via late domains identified in some FV capsid proteins. Additionally, there are features of the FV budding strategy quite unique to the spumaretroviruses. This includes secretion of non-infectious subviral particles and a strict dependence on capsid-glycoprotein interaction for release of infectious virions from the cells. Virus-like particle release is not possible since FV capsid proteins lack a membrane-targeting signal. It is noteworthy that in experimental systems, the important capsid-glycoprotein interaction could be bypassed by fusing heterologous membrane-targeting signals to the capsid protein, thus enabling glycoprotein-independent egress. Aside from that, other systems have been developed to enable envelopment of FV capsids by heterologous Env proteins. In this review article, we will summarize the current knowledge on FV budding, the viral components and their domains involved as well as alternative and artificial ways to promote budding of FV particle structures, a feature important for alteration of target tissue tropism of FV-based gene transfer systems.
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spelling pubmed-37052662013-07-09 Foamy Virus Budding and Release Hütter, Sylvia Zurnic, Irena Lindemann, Dirk Viruses Review Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction of the capsid protein with components of cellular vacuolar protein sorting (Vps) machinery via late domains identified in some FV capsid proteins. Additionally, there are features of the FV budding strategy quite unique to the spumaretroviruses. This includes secretion of non-infectious subviral particles and a strict dependence on capsid-glycoprotein interaction for release of infectious virions from the cells. Virus-like particle release is not possible since FV capsid proteins lack a membrane-targeting signal. It is noteworthy that in experimental systems, the important capsid-glycoprotein interaction could be bypassed by fusing heterologous membrane-targeting signals to the capsid protein, thus enabling glycoprotein-independent egress. Aside from that, other systems have been developed to enable envelopment of FV capsids by heterologous Env proteins. In this review article, we will summarize the current knowledge on FV budding, the viral components and their domains involved as well as alternative and artificial ways to promote budding of FV particle structures, a feature important for alteration of target tissue tropism of FV-based gene transfer systems. MDPI 2013-04-10 /pmc/articles/PMC3705266/ /pubmed/23575110 http://dx.doi.org/10.3390/v5041075 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hütter, Sylvia
Zurnic, Irena
Lindemann, Dirk
Foamy Virus Budding and Release
title Foamy Virus Budding and Release
title_full Foamy Virus Budding and Release
title_fullStr Foamy Virus Budding and Release
title_full_unstemmed Foamy Virus Budding and Release
title_short Foamy Virus Budding and Release
title_sort foamy virus budding and release
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705266/
https://www.ncbi.nlm.nih.gov/pubmed/23575110
http://dx.doi.org/10.3390/v5041075
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