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Hepatitis C Virus-Induced Mitochondrial Dysfunctions
Chronic hepatitis C is characterized by metabolic disorders and a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that lead in the long term to hepatocellular carcinoma. Many lines of evidence suggest that mitochondrial dysfunctions, including mod...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705306/ https://www.ncbi.nlm.nih.gov/pubmed/23518579 http://dx.doi.org/10.3390/v5030954 |
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author | Brault, Charlène Levy, Pierre L. Bartosch, Birke |
author_facet | Brault, Charlène Levy, Pierre L. Bartosch, Birke |
author_sort | Brault, Charlène |
collection | PubMed |
description | Chronic hepatitis C is characterized by metabolic disorders and a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that lead in the long term to hepatocellular carcinoma. Many lines of evidence suggest that mitochondrial dysfunctions, including modification of metabolic fluxes, generation and elimination of oxidative stress, Ca(2+) signaling and apoptosis, play a central role in these processes. However, how these dysfunctions are induced by the virus and whether they play a role in disease progression and neoplastic transformation remains to be determined. Most in vitro studies performed so far have shown that several of the hepatitis C virus (HCV) proteins localize to mitochondria, but the consequences of these interactions on mitochondrial functions remain contradictory, probably due to the use of artificial expression and replication systems. In vivo studies are hampered by the fact that innate and adaptive immune responses will overlay mitochondrial dysfunctions induced directly in the hepatocyte by HCV. Thus, the molecular aspects underlying HCV-induced mitochondrial dysfunctions and their roles in viral replication and the associated pathology need yet to be confirmed in the context of productively replicating virus and physiologically relevant in vitro and in vivo model systems. |
format | Online Article Text |
id | pubmed-3705306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37053062013-07-09 Hepatitis C Virus-Induced Mitochondrial Dysfunctions Brault, Charlène Levy, Pierre L. Bartosch, Birke Viruses Review Chronic hepatitis C is characterized by metabolic disorders and a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that lead in the long term to hepatocellular carcinoma. Many lines of evidence suggest that mitochondrial dysfunctions, including modification of metabolic fluxes, generation and elimination of oxidative stress, Ca(2+) signaling and apoptosis, play a central role in these processes. However, how these dysfunctions are induced by the virus and whether they play a role in disease progression and neoplastic transformation remains to be determined. Most in vitro studies performed so far have shown that several of the hepatitis C virus (HCV) proteins localize to mitochondria, but the consequences of these interactions on mitochondrial functions remain contradictory, probably due to the use of artificial expression and replication systems. In vivo studies are hampered by the fact that innate and adaptive immune responses will overlay mitochondrial dysfunctions induced directly in the hepatocyte by HCV. Thus, the molecular aspects underlying HCV-induced mitochondrial dysfunctions and their roles in viral replication and the associated pathology need yet to be confirmed in the context of productively replicating virus and physiologically relevant in vitro and in vivo model systems. MDPI 2013-03-21 /pmc/articles/PMC3705306/ /pubmed/23518579 http://dx.doi.org/10.3390/v5030954 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Brault, Charlène Levy, Pierre L. Bartosch, Birke Hepatitis C Virus-Induced Mitochondrial Dysfunctions |
title | Hepatitis C Virus-Induced Mitochondrial Dysfunctions |
title_full | Hepatitis C Virus-Induced Mitochondrial Dysfunctions |
title_fullStr | Hepatitis C Virus-Induced Mitochondrial Dysfunctions |
title_full_unstemmed | Hepatitis C Virus-Induced Mitochondrial Dysfunctions |
title_short | Hepatitis C Virus-Induced Mitochondrial Dysfunctions |
title_sort | hepatitis c virus-induced mitochondrial dysfunctions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705306/ https://www.ncbi.nlm.nih.gov/pubmed/23518579 http://dx.doi.org/10.3390/v5030954 |
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