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Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp
Seven new polyoxygenated steroids (1–7) were isolated together with seven known analogues (8–14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705369/ https://www.ncbi.nlm.nih.gov/pubmed/23478486 http://dx.doi.org/10.3390/md11030775 |
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author | Wang, Zenglei Tang, Hua Wang, Pan Gong, Wei Xue, Mei Zhang, Hongwei Liu, Taofang Liu, Baoshu Yi, Yanghua Zhang, Wen |
author_facet | Wang, Zenglei Tang, Hua Wang, Pan Gong, Wei Xue, Mei Zhang, Hongwei Liu, Taofang Liu, Baoshu Yi, Yanghua Zhang, Wen |
author_sort | Wang, Zenglei |
collection | PubMed |
description | Seven new polyoxygenated steroids (1–7) were isolated together with seven known analogues (8–14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity. |
format | Online Article Text |
id | pubmed-3705369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37053692013-07-09 Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp Wang, Zenglei Tang, Hua Wang, Pan Gong, Wei Xue, Mei Zhang, Hongwei Liu, Taofang Liu, Baoshu Yi, Yanghua Zhang, Wen Mar Drugs Article Seven new polyoxygenated steroids (1–7) were isolated together with seven known analogues (8–14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity. MDPI 2013-03-11 /pmc/articles/PMC3705369/ /pubmed/23478486 http://dx.doi.org/10.3390/md11030775 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Wang, Zenglei Tang, Hua Wang, Pan Gong, Wei Xue, Mei Zhang, Hongwei Liu, Taofang Liu, Baoshu Yi, Yanghua Zhang, Wen Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp |
title | Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp |
title_full | Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp |
title_fullStr | Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp |
title_full_unstemmed | Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp |
title_short | Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp |
title_sort | bioactive polyoxygenated steroids from the south china sea soft coral, sarcophyton sp |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705369/ https://www.ncbi.nlm.nih.gov/pubmed/23478486 http://dx.doi.org/10.3390/md11030775 |
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