New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells

Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F(5a) monoester (1), 23-valine demalonylazalomycin F(5a) ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F(3a) ester (3), F...

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Detalles Bibliográficos
Autores principales: Yuan, Ganjun, Hong, Kui, Lin, Haipeng, She, Zhigang, Li, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705372/
https://www.ncbi.nlm.nih.gov/pubmed/23481678
http://dx.doi.org/10.3390/md11030817
Descripción
Sumario:Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F(5a) monoester (1), 23-valine demalonylazalomycin F(5a) ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F(3a) ester (3), F(4a) ester (4) and F(5a) ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F(4a) ester (6) and 23-(10-methyl)undecanoic acid demalonylazalomycin F(4a) ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F(3a), F(4a) and F(5a). Biological assays exhibited that 1–7 showed broad-spectrum antimicrobial and anti HCT-116 activities.

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