New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells

Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F(5a) monoester (1), 23-valine demalonylazalomycin F(5a) ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F(3a) ester (3), F...

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Detalles Bibliográficos
Autores principales: Yuan, Ganjun, Hong, Kui, Lin, Haipeng, She, Zhigang, Li, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705372/
https://www.ncbi.nlm.nih.gov/pubmed/23481678
http://dx.doi.org/10.3390/md11030817
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author Yuan, Ganjun
Hong, Kui
Lin, Haipeng
She, Zhigang
Li, Jia
author_facet Yuan, Ganjun
Hong, Kui
Lin, Haipeng
She, Zhigang
Li, Jia
author_sort Yuan, Ganjun
collection PubMed
description Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F(5a) monoester (1), 23-valine demalonylazalomycin F(5a) ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F(3a) ester (3), F(4a) ester (4) and F(5a) ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F(4a) ester (6) and 23-(10-methyl)undecanoic acid demalonylazalomycin F(4a) ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F(3a), F(4a) and F(5a). Biological assays exhibited that 1–7 showed broad-spectrum antimicrobial and anti HCT-116 activities.
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spelling pubmed-37053722013-07-09 New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells Yuan, Ganjun Hong, Kui Lin, Haipeng She, Zhigang Li, Jia Mar Drugs Article Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F(5a) monoester (1), 23-valine demalonylazalomycin F(5a) ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F(3a) ester (3), F(4a) ester (4) and F(5a) ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F(4a) ester (6) and 23-(10-methyl)undecanoic acid demalonylazalomycin F(4a) ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F(3a), F(4a) and F(5a). Biological assays exhibited that 1–7 showed broad-spectrum antimicrobial and anti HCT-116 activities. MDPI 2013-03-12 /pmc/articles/PMC3705372/ /pubmed/23481678 http://dx.doi.org/10.3390/md11030817 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yuan, Ganjun
Hong, Kui
Lin, Haipeng
She, Zhigang
Li, Jia
New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
title New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
title_full New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
title_fullStr New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
title_full_unstemmed New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
title_short New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
title_sort new azalomycin f analogs from mangrove streptomyces sp. 211726 with activity against microbes and cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705372/
https://www.ncbi.nlm.nih.gov/pubmed/23481678
http://dx.doi.org/10.3390/md11030817
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