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The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. Furthermore, OA conveys critical deleterious effects for marine organisms due to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705373/ https://www.ncbi.nlm.nih.gov/pubmed/23481679 http://dx.doi.org/10.3390/md11030830 |
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author | Suárez-Ulloa, Victoria Fernández-Tajes, Juan Aguiar-Pulido, Vanessa Rivera-Casas, Ciro González-Romero, Rodrigo Ausio, Juan Méndez, Josefina Dorado, Julián Eirín-López, José M. |
author_facet | Suárez-Ulloa, Victoria Fernández-Tajes, Juan Aguiar-Pulido, Vanessa Rivera-Casas, Ciro González-Romero, Rodrigo Ausio, Juan Méndez, Josefina Dorado, Julián Eirín-López, José M. |
author_sort | Suárez-Ulloa, Victoria |
collection | PubMed |
description | Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. Furthermore, OA conveys critical deleterious effects for marine organisms due to its genotoxic potential. Many efforts have been dedicated to OA biomonitoring during the last three decades. However, it is only now with the current availability of detailed molecular information on DNA organization and the mechanisms involved in the maintenance of genome integrity, that a new arena starts opening up for the study of OA contamination. In the present work we address the links between OA genotoxicity and chromatin by combining Next Generation Sequencing (NGS) technologies and bioinformatics. To this end, we introduce CHROMEVALOAdb, a public database containing the chromatin-associated transcriptome of the mussel Mytilus galloprovincialis (a sentinel model organism) in response to OA exposure. This resource constitutes a leap forward for the development of chromatin-based biomarkers, paving the road towards the generation of powerful and sensitive tests for the detection and evaluation of the genotoxic effects of OA in coastal areas. |
format | Online Article Text |
id | pubmed-3705373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37053732013-07-09 The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis Suárez-Ulloa, Victoria Fernández-Tajes, Juan Aguiar-Pulido, Vanessa Rivera-Casas, Ciro González-Romero, Rodrigo Ausio, Juan Méndez, Josefina Dorado, Julián Eirín-López, José M. Mar Drugs Article Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. Furthermore, OA conveys critical deleterious effects for marine organisms due to its genotoxic potential. Many efforts have been dedicated to OA biomonitoring during the last three decades. However, it is only now with the current availability of detailed molecular information on DNA organization and the mechanisms involved in the maintenance of genome integrity, that a new arena starts opening up for the study of OA contamination. In the present work we address the links between OA genotoxicity and chromatin by combining Next Generation Sequencing (NGS) technologies and bioinformatics. To this end, we introduce CHROMEVALOAdb, a public database containing the chromatin-associated transcriptome of the mussel Mytilus galloprovincialis (a sentinel model organism) in response to OA exposure. This resource constitutes a leap forward for the development of chromatin-based biomarkers, paving the road towards the generation of powerful and sensitive tests for the detection and evaluation of the genotoxic effects of OA in coastal areas. MDPI 2013-03-12 /pmc/articles/PMC3705373/ /pubmed/23481679 http://dx.doi.org/10.3390/md11030830 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Suárez-Ulloa, Victoria Fernández-Tajes, Juan Aguiar-Pulido, Vanessa Rivera-Casas, Ciro González-Romero, Rodrigo Ausio, Juan Méndez, Josefina Dorado, Julián Eirín-López, José M. The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis |
title | The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis |
title_full | The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis |
title_fullStr | The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis |
title_full_unstemmed | The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis |
title_short | The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis |
title_sort | chromevaloa database: a resource for the evaluation of okadaic acid contamination in the marine environment based on the chromatin-associated transcriptome of the mussel mytilus galloprovincialis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705373/ https://www.ncbi.nlm.nih.gov/pubmed/23481679 http://dx.doi.org/10.3390/md11030830 |
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