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Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705393/ https://www.ncbi.nlm.nih.gov/pubmed/23549284 http://dx.doi.org/10.3390/md11041126 |
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author | Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina |
author_facet | Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina |
author_sort | Turk, Tom |
collection | PubMed |
description | We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. |
format | Online Article Text |
id | pubmed-3705393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37053932013-07-09 Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina Mar Drugs Article We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. MDPI 2013-04-02 /pmc/articles/PMC3705393/ /pubmed/23549284 http://dx.doi.org/10.3390/md11041126 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title | Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_full | Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_fullStr | Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_full_unstemmed | Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_short | Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges |
title_sort | biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705393/ https://www.ncbi.nlm.nih.gov/pubmed/23549284 http://dx.doi.org/10.3390/md11041126 |
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