Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp

Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*,4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E,11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-o...

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Autores principales: Zhao, Min, Yin, Jian, Jiang, Wei, Ma, Minshan, Lei, Xinxiang, Xiang, Zheng, Dong, Jianyong, Huang, Kexin, Yan, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705396/
https://www.ncbi.nlm.nih.gov/pubmed/23552878
http://dx.doi.org/10.3390/md11041162
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author Zhao, Min
Yin, Jian
Jiang, Wei
Ma, Minshan
Lei, Xinxiang
Xiang, Zheng
Dong, Jianyong
Huang, Kexin
Yan, Pengcheng
author_facet Zhao, Min
Yin, Jian
Jiang, Wei
Ma, Minshan
Lei, Xinxiang
Xiang, Zheng
Dong, Jianyong
Huang, Kexin
Yan, Pengcheng
author_sort Zhao, Min
collection PubMed
description Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*,4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E,11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*,3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4–14. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1–3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
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spelling pubmed-37053962013-07-09 Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp Zhao, Min Yin, Jian Jiang, Wei Ma, Minshan Lei, Xinxiang Xiang, Zheng Dong, Jianyong Huang, Kexin Yan, Pengcheng Mar Drugs Article Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*,4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E,11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*,3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4–14. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1–3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae. MDPI 2013-04-03 /pmc/articles/PMC3705396/ /pubmed/23552878 http://dx.doi.org/10.3390/md11041162 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhao, Min
Yin, Jian
Jiang, Wei
Ma, Minshan
Lei, Xinxiang
Xiang, Zheng
Dong, Jianyong
Huang, Kexin
Yan, Pengcheng
Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp
title Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp
title_full Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp
title_fullStr Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp
title_full_unstemmed Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp
title_short Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp
title_sort cytotoxic and antibacterial cembranoids from a south china sea soft coral, lobophytum sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705396/
https://www.ncbi.nlm.nih.gov/pubmed/23552878
http://dx.doi.org/10.3390/md11041162
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