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Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation

Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken i...

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Autores principales: Carvalho, Vinicius, Fernandes, Lohengrin, Conde, Taline, Zamith, Helena, Silva, Ronald, Surrage, Andrea, Frutuoso, Valber, Castro-Faria-Neto, Hugo, Amendoeira, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705400/
https://www.ncbi.nlm.nih.gov/pubmed/23574984
http://dx.doi.org/10.3390/md11041221
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author Carvalho, Vinicius
Fernandes, Lohengrin
Conde, Taline
Zamith, Helena
Silva, Ronald
Surrage, Andrea
Frutuoso, Valber
Castro-Faria-Neto, Hugo
Amendoeira, Fabio
author_facet Carvalho, Vinicius
Fernandes, Lohengrin
Conde, Taline
Zamith, Helena
Silva, Ronald
Surrage, Andrea
Frutuoso, Valber
Castro-Faria-Neto, Hugo
Amendoeira, Fabio
author_sort Carvalho, Vinicius
collection PubMed
description Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain.
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spelling pubmed-37054002013-07-09 Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Zamith, Helena Silva, Ronald Surrage, Andrea Frutuoso, Valber Castro-Faria-Neto, Hugo Amendoeira, Fabio Mar Drugs Article Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain. MDPI 2013-04-10 /pmc/articles/PMC3705400/ /pubmed/23574984 http://dx.doi.org/10.3390/md11041221 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Carvalho, Vinicius
Fernandes, Lohengrin
Conde, Taline
Zamith, Helena
Silva, Ronald
Surrage, Andrea
Frutuoso, Valber
Castro-Faria-Neto, Hugo
Amendoeira, Fabio
Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
title Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
title_full Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
title_fullStr Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
title_full_unstemmed Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
title_short Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
title_sort antinociceptive activity of stephanolepis hispidus skin aqueous extract depends partly on opioid system activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705400/
https://www.ncbi.nlm.nih.gov/pubmed/23574984
http://dx.doi.org/10.3390/md11041221
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