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Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation
Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705400/ https://www.ncbi.nlm.nih.gov/pubmed/23574984 http://dx.doi.org/10.3390/md11041221 |
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author | Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Zamith, Helena Silva, Ronald Surrage, Andrea Frutuoso, Valber Castro-Faria-Neto, Hugo Amendoeira, Fabio |
author_facet | Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Zamith, Helena Silva, Ronald Surrage, Andrea Frutuoso, Valber Castro-Faria-Neto, Hugo Amendoeira, Fabio |
author_sort | Carvalho, Vinicius |
collection | PubMed |
description | Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain. |
format | Online Article Text |
id | pubmed-3705400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37054002013-07-09 Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Zamith, Helena Silva, Ronald Surrage, Andrea Frutuoso, Valber Castro-Faria-Neto, Hugo Amendoeira, Fabio Mar Drugs Article Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain. MDPI 2013-04-10 /pmc/articles/PMC3705400/ /pubmed/23574984 http://dx.doi.org/10.3390/md11041221 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Carvalho, Vinicius Fernandes, Lohengrin Conde, Taline Zamith, Helena Silva, Ronald Surrage, Andrea Frutuoso, Valber Castro-Faria-Neto, Hugo Amendoeira, Fabio Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation |
title | Antinociceptive Activity of Stephanolepis
hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation |
title_full | Antinociceptive Activity of Stephanolepis
hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation |
title_fullStr | Antinociceptive Activity of Stephanolepis
hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation |
title_full_unstemmed | Antinociceptive Activity of Stephanolepis
hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation |
title_short | Antinociceptive Activity of Stephanolepis
hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation |
title_sort | antinociceptive activity of stephanolepis
hispidus skin aqueous extract depends partly on opioid system activation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705400/ https://www.ncbi.nlm.nih.gov/pubmed/23574984 http://dx.doi.org/10.3390/md11041221 |
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