Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR tech...

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Detalles Bibliográficos
Autores principales: Wu, Guangwei, Lin, Aiqun, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411/
https://www.ncbi.nlm.nih.gov/pubmed/23612371
http://dx.doi.org/10.3390/md11041399
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author Wu, Guangwei
Lin, Aiqun
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
author_facet Wu, Guangwei
Lin, Aiqun
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
author_sort Wu, Guangwei
collection PubMed
description A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.
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spelling pubmed-37054112013-07-09 Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 Wu, Guangwei Lin, Aiqun Gu, Qianqun Zhu, Tianjiao Li, Dehai Mar Drugs Article A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. MDPI 2013-04-23 /pmc/articles/PMC3705411/ /pubmed/23612371 http://dx.doi.org/10.3390/md11041399 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Guangwei
Lin, Aiqun
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_fullStr Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full_unstemmed Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_short Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_sort four new chloro-eremophilane sesquiterpenes from an antarctic deep-sea derived fungus, penicillium sp. pr19n-1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411/
https://www.ncbi.nlm.nih.gov/pubmed/23612371
http://dx.doi.org/10.3390/md11041399
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