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Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

In addition to their well-established role(s) in the pathogenesis of gastrointestinal (GI)-related inflammatory disorders, including inflammatory bowel disease (IBD) and inflammation-associated colorectal cancer (CRC), emerging evidence confirms the critical involvement of the interleukin-1 (IL-1) c...

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Autores principales: Lopetuso, Loris R., Chowdhry, Saleem, Pizarro, Theresa T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705591/
https://www.ncbi.nlm.nih.gov/pubmed/23847622
http://dx.doi.org/10.3389/fimmu.2013.00181
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author Lopetuso, Loris R.
Chowdhry, Saleem
Pizarro, Theresa T.
author_facet Lopetuso, Loris R.
Chowdhry, Saleem
Pizarro, Theresa T.
author_sort Lopetuso, Loris R.
collection PubMed
description In addition to their well-established role(s) in the pathogenesis of gastrointestinal (GI)-related inflammatory disorders, including inflammatory bowel disease (IBD) and inflammation-associated colorectal cancer (CRC), emerging evidence confirms the critical involvement of the interleukin-1 (IL-1) cytokine family and their ligands in the maintenance of normal gut homeostasis. In fact, the paradigm that IBD occurs in two distinct phases is substantiated by the observation that classic IL-1 family members, such as IL-1, the IL-1 receptor antagonist (IL-1Ra), and IL-18, possess dichotomous functions depending on the phase of disease, as well as on their role in initiating vs. sustaining chronic gut inflammation. Another recently characterized IL-1 family member, IL-33, also possesses dual functions in the gut. IL-33 is upregulated in IBD and potently induces Th2 immune responses, while also amplifying Th1-mediated inflammation. Neutralization studies in acute colitis models, however, have yielded controversial results and recent reports suggest a protective role of IL-33 in epithelial regeneration and mucosal wound healing. Finally, although little is currently known regarding the potential contribution of IL-36 family members in GI inflammation/homeostasis, another IL-1 family member, IL-37, is emerging as a potent anti-inflammatory cytokine with the ability to down-regulate colitis. This new body of information has important translational implications for both the prevention and treatment of patients suffering from IBD and inflammation-associated CRC.
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spelling pubmed-37055912013-07-11 Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease Lopetuso, Loris R. Chowdhry, Saleem Pizarro, Theresa T. Front Immunol Immunology In addition to their well-established role(s) in the pathogenesis of gastrointestinal (GI)-related inflammatory disorders, including inflammatory bowel disease (IBD) and inflammation-associated colorectal cancer (CRC), emerging evidence confirms the critical involvement of the interleukin-1 (IL-1) cytokine family and their ligands in the maintenance of normal gut homeostasis. In fact, the paradigm that IBD occurs in two distinct phases is substantiated by the observation that classic IL-1 family members, such as IL-1, the IL-1 receptor antagonist (IL-1Ra), and IL-18, possess dichotomous functions depending on the phase of disease, as well as on their role in initiating vs. sustaining chronic gut inflammation. Another recently characterized IL-1 family member, IL-33, also possesses dual functions in the gut. IL-33 is upregulated in IBD and potently induces Th2 immune responses, while also amplifying Th1-mediated inflammation. Neutralization studies in acute colitis models, however, have yielded controversial results and recent reports suggest a protective role of IL-33 in epithelial regeneration and mucosal wound healing. Finally, although little is currently known regarding the potential contribution of IL-36 family members in GI inflammation/homeostasis, another IL-1 family member, IL-37, is emerging as a potent anti-inflammatory cytokine with the ability to down-regulate colitis. This new body of information has important translational implications for both the prevention and treatment of patients suffering from IBD and inflammation-associated CRC. Frontiers Media S.A. 2013-07-09 /pmc/articles/PMC3705591/ /pubmed/23847622 http://dx.doi.org/10.3389/fimmu.2013.00181 Text en Copyright © 2013 Lopetuso, Chowdhry and Pizarro. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Lopetuso, Loris R.
Chowdhry, Saleem
Pizarro, Theresa T.
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease
title Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease
title_full Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease
title_fullStr Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease
title_full_unstemmed Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease
title_short Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease
title_sort opposing functions of classic and novel il-1 family members in gut health and disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705591/
https://www.ncbi.nlm.nih.gov/pubmed/23847622
http://dx.doi.org/10.3389/fimmu.2013.00181
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