Cargando…

Exploring GpG bases next to anticodon in tRNA subsets

Transfer RNA (tRNA) structure, modifications and functions are evolutionary and established in bacteria, archaea and eukaryotes. Typically the tRNA modifications are indispensable for its stability and are required for decoding the mRNA into amino acids for protein synthesis. A conserved methylation...

Descripción completa

Detalles Bibliográficos
Autores principales: Srinivasan, Thangavelu, Kumaran, Kubendiran, Selvakumar, Rajendran, Velmurugan, Devadasan, Sudarsanam, Dorairaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705617/
https://www.ncbi.nlm.nih.gov/pubmed/23847401
http://dx.doi.org/10.6026/97320630009466
_version_ 1782476467163103232
author Srinivasan, Thangavelu
Kumaran, Kubendiran
Selvakumar, Rajendran
Velmurugan, Devadasan
Sudarsanam, Dorairaj
author_facet Srinivasan, Thangavelu
Kumaran, Kubendiran
Selvakumar, Rajendran
Velmurugan, Devadasan
Sudarsanam, Dorairaj
author_sort Srinivasan, Thangavelu
collection PubMed
description Transfer RNA (tRNA) structure, modifications and functions are evolutionary and established in bacteria, archaea and eukaryotes. Typically the tRNA modifications are indispensable for its stability and are required for decoding the mRNA into amino acids for protein synthesis. A conserved methylation has been located on the anticodon loop specifically at the 37(th) position and it is next to the anticodon bases. This modification is called as m1G37 and it is catalyzed by tRNA (m(1)G37) methyltransferase (TrmD). It is deciphered that G37 positions occur on few additional amino acids specific tRNA subsets in bacteria. Furthermore, Archaea and Eukaryotes have more number of tRNA subsets which contains G37 position next to the anticodon and the G residue are located at different positions such as G36, G37, G38, 39, and G40. In eight bacterial species, G (guanosine) residues are presents at the 37(th) and 38(th) position except three tRNA subsets having G residues at 36(th) and 39(th) positions. Therefore we propose that m1G37 modification may be feasible at 36(th), 37(th), 38(th), 39(th) and 40(th) positions next to the anticodon of tRNAs. Collectively, methylation at G residues close to the anticodon may be possible at different positions and without restriction of anticodon 3(rd) base A, C, U or G.
format Online
Article
Text
id pubmed-3705617
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Biomedical Informatics
record_format MEDLINE/PubMed
spelling pubmed-37056172013-07-11 Exploring GpG bases next to anticodon in tRNA subsets Srinivasan, Thangavelu Kumaran, Kubendiran Selvakumar, Rajendran Velmurugan, Devadasan Sudarsanam, Dorairaj Bioinformation Hypothesis Transfer RNA (tRNA) structure, modifications and functions are evolutionary and established in bacteria, archaea and eukaryotes. Typically the tRNA modifications are indispensable for its stability and are required for decoding the mRNA into amino acids for protein synthesis. A conserved methylation has been located on the anticodon loop specifically at the 37(th) position and it is next to the anticodon bases. This modification is called as m1G37 and it is catalyzed by tRNA (m(1)G37) methyltransferase (TrmD). It is deciphered that G37 positions occur on few additional amino acids specific tRNA subsets in bacteria. Furthermore, Archaea and Eukaryotes have more number of tRNA subsets which contains G37 position next to the anticodon and the G residue are located at different positions such as G36, G37, G38, 39, and G40. In eight bacterial species, G (guanosine) residues are presents at the 37(th) and 38(th) position except three tRNA subsets having G residues at 36(th) and 39(th) positions. Therefore we propose that m1G37 modification may be feasible at 36(th), 37(th), 38(th), 39(th) and 40(th) positions next to the anticodon of tRNAs. Collectively, methylation at G residues close to the anticodon may be possible at different positions and without restriction of anticodon 3(rd) base A, C, U or G. Biomedical Informatics 2013-05-25 /pmc/articles/PMC3705617/ /pubmed/23847401 http://dx.doi.org/10.6026/97320630009466 Text en © 2013 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Srinivasan, Thangavelu
Kumaran, Kubendiran
Selvakumar, Rajendran
Velmurugan, Devadasan
Sudarsanam, Dorairaj
Exploring GpG bases next to anticodon in tRNA subsets
title Exploring GpG bases next to anticodon in tRNA subsets
title_full Exploring GpG bases next to anticodon in tRNA subsets
title_fullStr Exploring GpG bases next to anticodon in tRNA subsets
title_full_unstemmed Exploring GpG bases next to anticodon in tRNA subsets
title_short Exploring GpG bases next to anticodon in tRNA subsets
title_sort exploring gpg bases next to anticodon in trna subsets
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705617/
https://www.ncbi.nlm.nih.gov/pubmed/23847401
http://dx.doi.org/10.6026/97320630009466
work_keys_str_mv AT srinivasanthangavelu exploringgpgbasesnexttoanticodonintrnasubsets
AT kumarankubendiran exploringgpgbasesnexttoanticodonintrnasubsets
AT selvakumarrajendran exploringgpgbasesnexttoanticodonintrnasubsets
AT velmurugandevadasan exploringgpgbasesnexttoanticodonintrnasubsets
AT sudarsanamdorairaj exploringgpgbasesnexttoanticodonintrnasubsets