Insight from γC1 protein model for implication in cotton leaf curl disease

DNA γ is approximately half of the size of Begomovirus DNA. It encodes a γC1 gene that is conserved in position and size. This gene has the capacity to encode a 13 to 14 kDa protein comprising 118 amino acid residues. It has been shown earlier that γC1 protein is necessary for inducing symptoms of c...

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Autores principales: Shahzad, Khuram, Hai, Abdul, Kizilbash, Nadeem, Ambreen, Jawaria, Alruwaili, Jamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2013
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705618/
https://www.ncbi.nlm.nih.gov/pubmed/23847402
http://dx.doi.org/10.6026/97320630009471
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author Shahzad, Khuram
Hai, Abdul
Kizilbash, Nadeem
Ambreen, Jawaria
Alruwaili, Jamal
author_facet Shahzad, Khuram
Hai, Abdul
Kizilbash, Nadeem
Ambreen, Jawaria
Alruwaili, Jamal
author_sort Shahzad, Khuram
collection PubMed
description DNA γ is approximately half of the size of Begomovirus DNA. It encodes a γC1 gene that is conserved in position and size. This gene has the capacity to encode a 13 to 14 kDa protein comprising 118 amino acid residues. It has been shown earlier that γC1 protein is necessary for inducing symptoms of cotton leaf curl disease. The structure for γC1 (CLCuDγ01-Pakistan) is still unknown. Therefore, a model of γC1 (CLCuDγ01-Pakistan) was developed using DoBo and I-TASSER servers followed by validation by PROCHECK and VERIFY 3D servers. The developed model provides an insight in a role for this multifunctional protein in causing Cotton Leaf Curl Disease (CLCuD). A possible function of this protein might be the suppression of RNAsilencing in cotton plants.
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spelling pubmed-37056182013-07-11 Insight from γC1 protein model for implication in cotton leaf curl disease Shahzad, Khuram Hai, Abdul Kizilbash, Nadeem Ambreen, Jawaria Alruwaili, Jamal Bioinformation Hypothesis DNA γ is approximately half of the size of Begomovirus DNA. It encodes a γC1 gene that is conserved in position and size. This gene has the capacity to encode a 13 to 14 kDa protein comprising 118 amino acid residues. It has been shown earlier that γC1 protein is necessary for inducing symptoms of cotton leaf curl disease. The structure for γC1 (CLCuDγ01-Pakistan) is still unknown. Therefore, a model of γC1 (CLCuDγ01-Pakistan) was developed using DoBo and I-TASSER servers followed by validation by PROCHECK and VERIFY 3D servers. The developed model provides an insight in a role for this multifunctional protein in causing Cotton Leaf Curl Disease (CLCuD). A possible function of this protein might be the suppression of RNAsilencing in cotton plants. Biomedical Informatics 2013-05-25 /pmc/articles/PMC3705618/ /pubmed/23847402 http://dx.doi.org/10.6026/97320630009471 Text en © 2013 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Shahzad, Khuram
Hai, Abdul
Kizilbash, Nadeem
Ambreen, Jawaria
Alruwaili, Jamal
Insight from γC1 protein model for implication in cotton leaf curl disease
title Insight from γC1 protein model for implication in cotton leaf curl disease
title_full Insight from γC1 protein model for implication in cotton leaf curl disease
title_fullStr Insight from γC1 protein model for implication in cotton leaf curl disease
title_full_unstemmed Insight from γC1 protein model for implication in cotton leaf curl disease
title_short Insight from γC1 protein model for implication in cotton leaf curl disease
title_sort insight from γc1 protein model for implication in cotton leaf curl disease
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705618/
https://www.ncbi.nlm.nih.gov/pubmed/23847402
http://dx.doi.org/10.6026/97320630009471
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