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Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo

Granisetron is a 5-HT(3) receptors antagonist used in the management of emesis associated with anticancer chemotherapy. It affects intestinal motility with constipating effect. Since the pathway heme oxygenase/carbon monoxide (HO/CO) is involved in gastrointestinal motility, we evaluated the possibl...

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Detalles Bibliográficos
Autores principales:	Zigrino, Addolorata, Leo, Valentina, Renna, Giuseppe, Montagnani, Monica, De Salvia, Maria Antonietta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705784/ https://www.ncbi.nlm.nih.gov/pubmed/23864955 http://dx.doi.org/10.1155/2013/612037

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