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Bone Effects of Biologic Drugs in Rheumatoid Arthritis

Biologic agents used in the treatment of rheumatoid arthritis (RA) are able to reduce both disease activity and radiographic progression of joint disease. These drugs are directed against several proinflammatory cytokines (TNFα, IL-6, and IL-1) which are involved both in the pathogenesis of chronic...

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Autores principales: Corrado, Addolorata, Neve, Anna, Maruotti, Nicola, Cantatore, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705836/
https://www.ncbi.nlm.nih.gov/pubmed/23864880
http://dx.doi.org/10.1155/2013/945945
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author Corrado, Addolorata
Neve, Anna
Maruotti, Nicola
Cantatore, Francesco Paolo
author_facet Corrado, Addolorata
Neve, Anna
Maruotti, Nicola
Cantatore, Francesco Paolo
author_sort Corrado, Addolorata
collection PubMed
description Biologic agents used in the treatment of rheumatoid arthritis (RA) are able to reduce both disease activity and radiographic progression of joint disease. These drugs are directed against several proinflammatory cytokines (TNFα, IL-6, and IL-1) which are involved both in the pathogenesis of chronic inflammation and progression of joint structural damage and in systemic and local bone loss typically observed in RA. However, the role of biologic drugs in preventing bone loss in clinical practice has not yet clearly assessed. Many clinical studies showed a trend to a positive effect of biologic agents in preventing systemic bone loss observed in RA. Although the suppression of inflammation is the main goal in the treatment of RA and the anti-inflammatory effects of biologic drugs exert a positive effect on bone metabolism, the exact relationship between the prevention of bone loss and control of inflammation has not been clearly established, and if the available biologic drugs against TNFα, IL-1, and IL-6 can exert their effect on systemic and local bone loss also through a direct mechanism on bone cell metabolism is still to be clearly defined.
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spelling pubmed-37058362013-07-17 Bone Effects of Biologic Drugs in Rheumatoid Arthritis Corrado, Addolorata Neve, Anna Maruotti, Nicola Cantatore, Francesco Paolo Clin Dev Immunol Review Article Biologic agents used in the treatment of rheumatoid arthritis (RA) are able to reduce both disease activity and radiographic progression of joint disease. These drugs are directed against several proinflammatory cytokines (TNFα, IL-6, and IL-1) which are involved both in the pathogenesis of chronic inflammation and progression of joint structural damage and in systemic and local bone loss typically observed in RA. However, the role of biologic drugs in preventing bone loss in clinical practice has not yet clearly assessed. Many clinical studies showed a trend to a positive effect of biologic agents in preventing systemic bone loss observed in RA. Although the suppression of inflammation is the main goal in the treatment of RA and the anti-inflammatory effects of biologic drugs exert a positive effect on bone metabolism, the exact relationship between the prevention of bone loss and control of inflammation has not been clearly established, and if the available biologic drugs against TNFα, IL-1, and IL-6 can exert their effect on systemic and local bone loss also through a direct mechanism on bone cell metabolism is still to be clearly defined. Hindawi Publishing Corporation 2013 2013-06-20 /pmc/articles/PMC3705836/ /pubmed/23864880 http://dx.doi.org/10.1155/2013/945945 Text en Copyright © 2013 Addolorata Corrado et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Corrado, Addolorata
Neve, Anna
Maruotti, Nicola
Cantatore, Francesco Paolo
Bone Effects of Biologic Drugs in Rheumatoid Arthritis
title Bone Effects of Biologic Drugs in Rheumatoid Arthritis
title_full Bone Effects of Biologic Drugs in Rheumatoid Arthritis
title_fullStr Bone Effects of Biologic Drugs in Rheumatoid Arthritis
title_full_unstemmed Bone Effects of Biologic Drugs in Rheumatoid Arthritis
title_short Bone Effects of Biologic Drugs in Rheumatoid Arthritis
title_sort bone effects of biologic drugs in rheumatoid arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705836/
https://www.ncbi.nlm.nih.gov/pubmed/23864880
http://dx.doi.org/10.1155/2013/945945
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