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Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5

Aconitum, widely used to treat rheumatoid arthritis for thousands of years, is a toxic herb that can frequently cause fatal cardiac poisoning. Aconitum toxicity could be decreased by properly hydrolyzing diester-diterpene alkaloids into monoester-diterpene alkaloids. Monoester-diterpene alkaloids, i...

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Detalles Bibliográficos
Autores principales:	Ye, Ling, Yang, Xiao-Shan, Lu, Lin-lin, Chen, Wei-Ying, Zeng, Shan, Yan, Tong-Meng, Dong, Ling-Na, Peng, Xiao-Juan, Shi, Jian, Liu, Zhong-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705941/ https://www.ncbi.nlm.nih.gov/pubmed/23864901 http://dx.doi.org/10.1155/2013/941093

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