Cargando…

The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis

Background. The brain's inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury. The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Grandgirard, Denis, Gäumann, Rahel, Coulibaly, Boubacar, Dangy, Jean-Pierre, Sie, Ali, Junghanss, Thomas, Schudel, Hans, Pluschke, Gerd, Leib, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705964/
https://www.ncbi.nlm.nih.gov/pubmed/23864766
http://dx.doi.org/10.1155/2013/312476
_version_ 1782476502947856384
author Grandgirard, Denis
Gäumann, Rahel
Coulibaly, Boubacar
Dangy, Jean-Pierre
Sie, Ali
Junghanss, Thomas
Schudel, Hans
Pluschke, Gerd
Leib, Stephen L.
author_facet Grandgirard, Denis
Gäumann, Rahel
Coulibaly, Boubacar
Dangy, Jean-Pierre
Sie, Ali
Junghanss, Thomas
Schudel, Hans
Pluschke, Gerd
Leib, Stephen L.
author_sort Grandgirard, Denis
collection PubMed
description Background. The brain's inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury. The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) activating resident immune cells and leading to the influx of blood derived leukocytes. To elucidate the pathomechanisms behind the observed difference in outcome between different pathogens, we compared the inflammatory profile in the CSF of patients with BM caused by Streptococcus pneumonia (n = 14), Neisseria meningitidis (n = 22), and Haemophilus influenza (n = 9). Methods. CSF inflammatory parameters, including cytokines and chemokines, MMP-9, and nitric oxide synthase activity, were assessed in a cohort of patients with BM from Burkina Faso. Results. Pneumococcal meningitis was associated with significantly higher CSF concentrations of IFN-γ, MCP-1, and the matrix-metalloproteinase (MMP-) 9. In patients with a fatal outcome, levels of TNF-α, IL-1β, IL-1RA, IL-6, and TGF-α were significantly higher. Conclusion. The signature of pro- and anti-inflammatory mediators and the intensity of inflammatory processes in CSF are determined by the bacterial pathogen causing bacterial meningitis with pneumococcal meningitis being associated with a higher case fatality rate than meningitis caused by N. meningitidis or H. influenzae.
format Online
Article
Text
id pubmed-3705964
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37059642013-07-17 The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis Grandgirard, Denis Gäumann, Rahel Coulibaly, Boubacar Dangy, Jean-Pierre Sie, Ali Junghanss, Thomas Schudel, Hans Pluschke, Gerd Leib, Stephen L. Mediators Inflamm Research Article Background. The brain's inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury. The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) activating resident immune cells and leading to the influx of blood derived leukocytes. To elucidate the pathomechanisms behind the observed difference in outcome between different pathogens, we compared the inflammatory profile in the CSF of patients with BM caused by Streptococcus pneumonia (n = 14), Neisseria meningitidis (n = 22), and Haemophilus influenza (n = 9). Methods. CSF inflammatory parameters, including cytokines and chemokines, MMP-9, and nitric oxide synthase activity, were assessed in a cohort of patients with BM from Burkina Faso. Results. Pneumococcal meningitis was associated with significantly higher CSF concentrations of IFN-γ, MCP-1, and the matrix-metalloproteinase (MMP-) 9. In patients with a fatal outcome, levels of TNF-α, IL-1β, IL-1RA, IL-6, and TGF-α were significantly higher. Conclusion. The signature of pro- and anti-inflammatory mediators and the intensity of inflammatory processes in CSF are determined by the bacterial pathogen causing bacterial meningitis with pneumococcal meningitis being associated with a higher case fatality rate than meningitis caused by N. meningitidis or H. influenzae. Hindawi Publishing Corporation 2013 2013-06-20 /pmc/articles/PMC3705964/ /pubmed/23864766 http://dx.doi.org/10.1155/2013/312476 Text en Copyright © 2013 Denis Grandgirard et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grandgirard, Denis
Gäumann, Rahel
Coulibaly, Boubacar
Dangy, Jean-Pierre
Sie, Ali
Junghanss, Thomas
Schudel, Hans
Pluschke, Gerd
Leib, Stephen L.
The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
title The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
title_full The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
title_fullStr The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
title_full_unstemmed The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
title_short The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
title_sort causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705964/
https://www.ncbi.nlm.nih.gov/pubmed/23864766
http://dx.doi.org/10.1155/2013/312476
work_keys_str_mv AT grandgirarddenis thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT gaumannrahel thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT coulibalyboubacar thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT dangyjeanpierre thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT sieali thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT junghanssthomas thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT schudelhans thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT pluschkegerd thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT leibstephenl thecausativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT grandgirarddenis causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT gaumannrahel causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT coulibalyboubacar causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT dangyjeanpierre causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT sieali causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT junghanssthomas causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT schudelhans causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT pluschkegerd causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis
AT leibstephenl causativepathogendeterminestheinflammatoryprofileincerebrospinalfluidandoutcomeinpatientswithbacterialmeningitis