Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management

G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes. The current review gives an overview of the general characteristics of GPCRs and their role in physiological conditions. In addition, it describes the current knowledge of the physiological and pathophysiological functi...

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Detalles Bibliográficos
Autores principales: Leyva-Illades, Dinorah, DeMorrow, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706254/
https://www.ncbi.nlm.nih.gov/pubmed/23869178
http://dx.doi.org/10.2147/CMAR.S35175
Descripción
Sumario:G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes. The current review gives an overview of the general characteristics of GPCRs and their role in physiological conditions. In addition, it describes the current knowledge of the physiological and pathophysiological functions of GPR55, an orphan GPCR, and how it can be exploited as a therapeutic target to combat various cancers.

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