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Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival

BACKGROUND: Glioblastoma multiforme (GBM) is one of the most aggressive forms of cancer with a high rate of recurrence. We propose a novel oncolytic vaccinia virus (VACV)-based therapy using expression of the bone morphogenetic protein (BMP)-4 for treating GBM and preventing recurrence. METHODS: We...

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Detalles Bibliográficos
Autores principales:	Duggal, Rohit, Geissinger, Ulrike, Zhang, Qian, Aguilar, Jason, Chen, Nanhai G, Binda, Elena, Vescovi, Angelo L, Szalay, Aladar A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706280/ https://www.ncbi.nlm.nih.gov/pubmed/23800258 http://dx.doi.org/10.1186/1479-5876-11-155

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