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Mesothelin Virus-Like Particle Immunization Controls Pancreatic Cancer Growth through CD8(+) T Cell Induction and Reduction in the Frequency of CD4(+)foxp3(+)ICOS(−) Regulatory T Cells

Our previous study has shown that mesothelin (MSLN) is a potential immunotherapeutic target for pancreatic cancer. Here, we further studied the immunogenicity of chimeric murine MSLN-virus-like particles (mMSLN-VLPs), their ability to break tolerance to mMSLN, a self-antigen, and deciphered the mech...

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Detalles Bibliográficos
Autores principales:	Zhang, Sheng, Yong, Lin-Kin, Li, Dali, Cubas, Rafael, Chen, Changyi, Yao, Qizhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706370/ https://www.ncbi.nlm.nih.gov/pubmed/23874581 http://dx.doi.org/10.1371/journal.pone.0068303

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