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Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women

BACKGROUND: Physical and Mental Component Summary (PCS, MCS, respectively) scales of SF- 36 health-related-quality-of-life have been associated with all-cause and cardiovascular disease (CVD) mortality. Their relationships with CVD incidence are unclear. This study purpose was to test whether PCS an...

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Autores principales: Saquib, Nazmus, Brunner, Robert, Kubo, Jessica, Tindle, Hilary, Kroenke, Candyce, Desai, Manisha, Daviglus, Martha L, Allen, Norrina, Martin, Lisa W, Robinson, Jennifer, Stefanick, Marcia L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706392/
https://www.ncbi.nlm.nih.gov/pubmed/23672763
http://dx.doi.org/10.1186/1471-2458-13-468
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author Saquib, Nazmus
Brunner, Robert
Kubo, Jessica
Tindle, Hilary
Kroenke, Candyce
Desai, Manisha
Daviglus, Martha L
Allen, Norrina
Martin, Lisa W
Robinson, Jennifer
Stefanick, Marcia L
author_facet Saquib, Nazmus
Brunner, Robert
Kubo, Jessica
Tindle, Hilary
Kroenke, Candyce
Desai, Manisha
Daviglus, Martha L
Allen, Norrina
Martin, Lisa W
Robinson, Jennifer
Stefanick, Marcia L
author_sort Saquib, Nazmus
collection PubMed
description BACKGROUND: Physical and Mental Component Summary (PCS, MCS, respectively) scales of SF- 36 health-related-quality-of-life have been associated with all-cause and cardiovascular disease (CVD) mortality. Their relationships with CVD incidence are unclear. This study purpose was to test whether PCS and/or MCS were associated with CVD incidence and death. METHODS: Postmenopausal women (aged 50–79 years) in control groups of the Women’s Health Initiative clinical trials (n = 20,308) completed the SF-36 and standardized questionnaires at trial entry. Health outcomes, assessed semi-annually, were verified with medical records. Cox regressions assessed time to selected outcomes during the trial phase (1993–2005). RESULTS: A total of 1075 incident CVD events, 204 CVD-specific deaths, and 1043 total deaths occurred during the trial phase. Women with low versus high baseline PCS scores had less favorable health profiles at baseline. In multivariable models adjusting for baseline confounders, participants in the lowest PCS quintile (reference = highest quintile) exhibited 1.8 (95%CI: 1.4, 2.3), 4.7 (95%CI: 2.3, 9.4), and 2.1 (95%CI: 1.7, 2.7) times greater risk of CVD incidence, CVD-specific death, and total mortality, respectively, by trial end; whereas, MCS was not significantly associated with CVD incidence or death. CONCLUSION: Physical health, assessed by self-report of physical functioning, is a strong predictor of CVD incidence and death in postmenopausal women; similar self-assessment of mental health is not. PCS should be evaluated as a screening tool to identify older women at high risk for CVD development and death.
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spelling pubmed-37063922013-07-10 Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women Saquib, Nazmus Brunner, Robert Kubo, Jessica Tindle, Hilary Kroenke, Candyce Desai, Manisha Daviglus, Martha L Allen, Norrina Martin, Lisa W Robinson, Jennifer Stefanick, Marcia L BMC Public Health Research Article BACKGROUND: Physical and Mental Component Summary (PCS, MCS, respectively) scales of SF- 36 health-related-quality-of-life have been associated with all-cause and cardiovascular disease (CVD) mortality. Their relationships with CVD incidence are unclear. This study purpose was to test whether PCS and/or MCS were associated with CVD incidence and death. METHODS: Postmenopausal women (aged 50–79 years) in control groups of the Women’s Health Initiative clinical trials (n = 20,308) completed the SF-36 and standardized questionnaires at trial entry. Health outcomes, assessed semi-annually, were verified with medical records. Cox regressions assessed time to selected outcomes during the trial phase (1993–2005). RESULTS: A total of 1075 incident CVD events, 204 CVD-specific deaths, and 1043 total deaths occurred during the trial phase. Women with low versus high baseline PCS scores had less favorable health profiles at baseline. In multivariable models adjusting for baseline confounders, participants in the lowest PCS quintile (reference = highest quintile) exhibited 1.8 (95%CI: 1.4, 2.3), 4.7 (95%CI: 2.3, 9.4), and 2.1 (95%CI: 1.7, 2.7) times greater risk of CVD incidence, CVD-specific death, and total mortality, respectively, by trial end; whereas, MCS was not significantly associated with CVD incidence or death. CONCLUSION: Physical health, assessed by self-report of physical functioning, is a strong predictor of CVD incidence and death in postmenopausal women; similar self-assessment of mental health is not. PCS should be evaluated as a screening tool to identify older women at high risk for CVD development and death. BioMed Central 2013-05-14 /pmc/articles/PMC3706392/ /pubmed/23672763 http://dx.doi.org/10.1186/1471-2458-13-468 Text en Copyright © 2013 Saquib et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Saquib, Nazmus
Brunner, Robert
Kubo, Jessica
Tindle, Hilary
Kroenke, Candyce
Desai, Manisha
Daviglus, Martha L
Allen, Norrina
Martin, Lisa W
Robinson, Jennifer
Stefanick, Marcia L
Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
title Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
title_full Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
title_fullStr Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
title_full_unstemmed Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
title_short Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
title_sort self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706392/
https://www.ncbi.nlm.nih.gov/pubmed/23672763
http://dx.doi.org/10.1186/1471-2458-13-468
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